Benzeneacetic acid, cyanomethyl ester

Base Information

• Chemical Name: Benzeneacetic acid, cyanomethyl ester
• CAS No.: 49808-65-3
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.187
• Mol file: 49808-65-3.mol

Synonyms:

Chemical Property of Benzeneacetic acid, cyanomethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, cyanomethyl ester

There total 3 articles about Benzeneacetic acid, cyanomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

phenylacetic acid (103-82-2) + chloroacetonitrile (107-14-2) → cyanomethyl 2-phenylacetate (49808-65-3)

Guidance literature:

With triethylamine; In dichloromethane; Ambient temperature;

DOI:10.1080/00397919208019271

Reference yield: 60.0%

phenylacetic acid (103-82-2) + acetonitrile (75-05-8,26809-02-9) → cyanomethyl 2-phenylacetate (49808-65-3)

Guidance literature:

With di-tert-butyl peroxide; C₁₁H₂₃N₂⁽¹⁺⁾*Br₄Fe^(1-); at 110 ℃; for 24h;

Reference yield:

→ cyanomethyl 2-phenylacetate (49808-65-3)

Guidance literature:

1.5 Mol Chloracetonitril, 1 Mol Phenylessigsaeure, 1.5 Mol Triaethylamin ;

upstream raw materials:

phenylacetic acid

chloroacetonitrile

acetonitrile

Refernces

• 1、 Hugel,Bhaskar,Longmore. "Cyanomethyl esters: Useful protection for carboxylic acids". . p. 693 - 697. Retrieved 2007/10/02.