1H-Indole-1-carboxylic acid, 3-[(2S)-3-[(4R)-4-(1-methylethyl)-2-oxo-3-oxazolidinyl]-3-oxo-2-[[[(phenyl methoxy)carbonyl]amino]methyl]propyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Indole-1-carboxylic acid, 3-[(2S)-3-[(4R)-4-(1-methylethyl)-2-oxo-3-oxazolidinyl]-3-oxo-2-[[[(phenyl methoxy)carbonyl]amino]methyl]propyl]-, 1,1-dimethylethyl ester
CAS No.:499136-28-6
Molecular Formula:C31H37N3O7
Molecular Weight:563.651
Hs Code.:

1H-Indole-1-carboxylic acid,
3-[(2S)-3-[(4R)-4-(1-methylethyl)-2-oxo-3-oxazolidinyl]-3-oxo-2-[[[(phenyl
methoxy)carbonyl]amino]methyl]propyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 1H-Indole-1-carboxylic acid, 3-[(2S)-3-[(4R)-4-(1-methylethyl)-2-oxo-3-oxazolidinyl]-3-oxo-2-[[[(phenyl methoxy)carbonyl]amino]methyl]propyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Indole-1-carboxylic acid, 3-[(2S)-3-[(4R)-4-(1-methylethyl)-2-oxo-3-oxazolidinyl]-3-oxo-2-[[[(phenyl methoxy)carbonyl]amino]methyl]propyl]-, 1,1-dimethylethyl ester

There total 5 articles about 1H-Indole-1-carboxylic acid, 3-[(2S)-3-[(4R)-4-(1-methylethyl)-2-oxo-3-oxazolidinyl]-3-oxo-2-[[[(phenyl methoxy)carbonyl]amino]methyl]propyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868632-19-3
(4R)-3-(3-{[(tert-butoxy)carbonyl]amino}-1-oxopropyl)-4-(1-methylethyl)oxazolidin-2-one

: 499136-28-6
(4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-{1-[(tert-butoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: Bu₂BOTf; Et₃N / CH₂Cl₂ / 1 h / -78 °C

1.2: CH₂Cl₂ / 3 h / -78 °C

2.1: 75 percent / Et₃SiH; BF₃*Et₂O / CH₂Cl₂ / 1 h / 0 °C

3.1: Zn powder / acetic acid / 1 h / 20 °C

4.1: 1.11 g / DMAP / acetonitrile / 0.5 h

With triethylsilane; dmap; di-n-butylboryl trifluoromethanesulfonate; boron trifluoride diethyl etherate; triethylamine; zinc; In dichloromethane; acetic acid; acetonitrile;
DOI:10.1002/hlca.200590157

Reference yield:

: 868632-26-2
(4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-{1-[(2,2,2-trichloroethoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one

: 499136-28-6
(4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-{1-[(tert-butoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: Zn powder / acetic acid / 1 h / 20 °C

2: 1.11 g / DMAP / acetonitrile / 0.5 h

With dmap; zinc; In acetic acid; acetonitrile;
DOI:10.1002/hlca.200590157

Reference yield:

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 499136-28-6
(4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-{1-[(tert-butoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: pivaloyl chloride; Et₃N / tetrahydrofuran / 2 h / -30 °C

1.2: 82 percent / LiCl / tetrahydrofuran / 36 h / -30 °C

2.1: Bu₂BOTf; Et₃N / CH₂Cl₂ / 1 h / -78 °C

2.2: CH₂Cl₂ / 3 h / -78 °C

3.1: 75 percent / Et₃SiH; BF₃*Et₂O / CH₂Cl₂ / 1 h / 0 °C

4.1: Zn powder / acetic acid / 1 h / 20 °C

5.1: 1.11 g / DMAP / acetonitrile / 0.5 h

With triethylsilane; dmap; di-n-butylboryl trifluoromethanesulfonate; boron trifluoride diethyl etherate; pivaloyl chloride; triethylamine; zinc; In tetrahydrofuran; dichloromethane; acetic acid; acetonitrile;
DOI:10.1002/hlca.200590157