(4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-{1-[(2,2,2-trichloroethoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one

Base Information

Chemical Name:(4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-{1-[(2,2,2-trichloroethoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one
CAS No.:868632-26-2
Molecular Formula:C₂₉H₃₀Cl₃N₃O₇
Molecular Weight:638.932
Hs Code.:

Synonyms:(4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-{1-[(2,2,2-trichloroethoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one

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Chemical Property of (4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-{1-[(2,2,2-trichloroethoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one

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Technology Process of (4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-{1-[(2,2,2-trichloroethoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one

There total 4 articles about (4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-{1-[(2,2,2-trichloroethoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 868632-20-6
(4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-hydroxy-3-{1-[(2,2,2-trichloroethoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one

: 868632-26-2
(4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-{1-[(2,2,2-trichloroethoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1002/hlca.200590157

Reference yield:

: 868632-19-3
(4R)-3-(3-{[(tert-butoxy)carbonyl]amino}-1-oxopropyl)-4-(1-methylethyl)oxazolidin-2-one

: 868632-26-2
(4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-{1-[(2,2,2-trichloroethoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: Bu₂BOTf; Et₃N / CH₂Cl₂ / 1 h / -78 °C

1.2: CH₂Cl₂ / 3 h / -78 °C

2.1: 75 percent / Et₃SiH; BF₃*Et₂O / CH₂Cl₂ / 1 h / 0 °C

With triethylsilane; di-n-butylboryl trifluoromethanesulfonate; boron trifluoride diethyl etherate; triethylamine; In dichloromethane;
DOI:10.1002/hlca.200590157

Reference yield:

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 868632-26-2
(4R)-3-[(2S)-2-({[(benzyoxy)carbonyl]amino}methyl)-3-{1-[(2,2,2-trichloroethoxy)carbonyl]-indolyl-3-yl}-1-oxopropyl]-4-(1-methylethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: pivaloyl chloride; Et₃N / tetrahydrofuran / 2 h / -30 °C

1.2: 82 percent / LiCl / tetrahydrofuran / 36 h / -30 °C

2.1: Bu₂BOTf; Et₃N / CH₂Cl₂ / 1 h / -78 °C

2.2: CH₂Cl₂ / 3 h / -78 °C

3.1: 75 percent / Et₃SiH; BF₃*Et₂O / CH₂Cl₂ / 1 h / 0 °C

With triethylsilane; di-n-butylboryl trifluoromethanesulfonate; boron trifluoride diethyl etherate; pivaloyl chloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.200590157