2-Propenoic acid, 3-[2-[2-(2-naphthalenyl)ethoxy]-4-(1H-pyrazol-1-ylmethyl)phenyl]-, (2E)-

Base Information

Chemical Name:2-Propenoic acid, 3-[2-[2-(2-naphthalenyl)ethoxy]-4-(1H-pyrazol-1-ylmethyl)phenyl]-, (2E)-
CAS No.:499143-62-3
Molecular Formula:C25H22N2O3
Molecular Weight:398.461
Hs Code.:

Synonyms:

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Chemical Property of 2-Propenoic acid, 3-[2-[2-(2-naphthalenyl)ethoxy]-4-(1H-pyrazol-1-ylmethyl)phenyl]-, (2E)-

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Technology Process of 2-Propenoic acid, 3-[2-[2-(2-naphthalenyl)ethoxy]-4-(1H-pyrazol-1-ylmethyl)phenyl]-, (2E)-

There total 9 articles about 2-Propenoic acid, 3-[2-[2-(2-naphthalenyl)ethoxy]-4-(1H-pyrazol-1-ylmethyl)phenyl]-, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: ethyl (2E)-3-(2-[2-(2-naphthyl)ethoxy]-4-(1H-pyrazol-1-ylmethyl)phenyl)acrylate

: 499143-62-3
(2E)-3-[2-[2-(2-naphthyl)ethoxy]-4-(1H-pyrazol-1-ylmethyl)phenyl]acrylic acid

Guidance literature:: ethyl (2E)-3-(2-[2-(2-naphthyl)ethoxy]-4-(1H-pyrazol-1-ylmethyl)phenyl)acrylate; With sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2009.08.007

Reference yield:

: hydrochloride of 3-hydroxy-4-aminobenzoic acid-methylester

: 499143-62-3
(2E)-3-[2-[2-(2-naphthyl)ethoxy]-4-(1H-pyrazol-1-ylmethyl)phenyl]acrylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.58 h

1.2: 1.33 h / 20 - 60 °C

2.1: triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 12 h / 20 °C

3.1: diisobutylaluminium hydride / hexane; dichloromethane / 1.17 h / -78 - -40 °C

4.1: triethylamine / 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate / dimethyl sulfoxide / 0.5 h / 100 °C

5.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 0.25 h

6.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.17 h / 0 °C

6.2: 1 h / 20 °C

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 50 °C

With hydrogenchloride; sodium hydroxide; water; sodium hydride; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; sodium nitrite; 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); hexane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 499157-25-4
(4-iodo-3-[2-(2-naphthyl)ethoxy]phenyl)methanol

: 499143-62-3
(2E)-3-[2-[2-(2-naphthyl)ethoxy]-4-(1H-pyrazol-1-ylmethyl)phenyl]acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate / dimethyl sulfoxide / 0.5 h / 100 °C

2.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 0.25 h

3.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.17 h / 0 °C

3.2: 1 h / 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 50 °C

With sodium hydroxide; water; sodium hydride; methanesulfonyl chloride; triethylamine; 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); dimethyl sulfoxide;