Lilolidine

Base Information

• Chemical Name: Lilolidine
• CAS No.: 5840-01-7
• Molecular Formula: C11H11 N
• Molecular Weight: 157.215
• Hs Code.: 29339900
• Mol file: 5840-01-7.mol

Synonyms:1,7-Trimethyleneindol;1,8-Trimethyleneindole; 5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinoline; Indole,1,7-(1,3-propanediyl)-; Lilolidene

Chemical Property of Lilolidine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 80-81°C
• Refractive Index: 1.656
• Boiling Point: 318.377 °C at 760 mmHg
• Flash Point: 146.349 °C
• PSA: 4.93000
• Density: 1.16 g/cm³
• LogP: 2.58750
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Lilodidine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Acts as a reagent primarily in reactions of ring-expansions with indoles.

Technology Process of Lilolidine

There total 17 articles about Lilolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1-carboxylic acid (124730-56-9) → 5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline (5840-01-7)

Guidance literature:

With quinoline; copper chromite; at 185 ℃; for 3h;

DOI:10.1021/jm00075a026

Reference yield: 88.9%

5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one (16078-37-8) → 5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline (5840-01-7)

Guidance literature:

5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one; With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -20 - -10 ℃;

With hydrogenchloride; In tetrahydrofuran; water; toluene; at 40 ℃; for 0.5h; Temperature; Concentration; Reagent/catalyst;

Reference yield: 72.0%

5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline 1,2-dicarboxylic acid (1220339-77-4) → 5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline (5840-01-7)

Guidance literature:

5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline 1,2-dicarboxylic acid; With quinoline; copper; at 238 ℃; for 3h;

With hydrogenchloride; In water;

With sodium hydroxide; In water;

upstream raw materials:

5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid

[(E)-8-Allyl-3,4-dihydro-2H-quinolin-1-ylimino]-acetic acid

5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1-carboxylic acid

1-allyl-7-bromo-1H-indole

Downstream raw materials:

5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-dione

Refernces

• 1、 Llabres-Campaner, Pedro J.,Ballesteros-Garrido, Rafael,Ballesteros, Rafael,Abarca, Belén. "β-Amino alcohols from anilines and ethylene glycol through heterogeneous Borrowing Hydrogen reaction". supporting information. p. 5552 - 5561. Retrieved 2017/08/22.
• 2、 -. "METHOD FOR PRODUCING TRICYCLIC HETEROCYCLIC COMPOUND". . . Retrieved 2016/06/06.