4H-PYRROLO[3,2,1-IJ]QUINOLINE-1-CARBOXYLIC ACID,5,6-DIHYDRO-

Base Information

• Chemical Name: 4H-PYRROLO[3,2,1-IJ]QUINOLINE-1-CARBOXYLIC ACID,5,6-DIHYDRO-
• CAS No.: 124730-56-9
• Molecular Formula: C12H11NO2
• Molecular Weight: 201.225
• Hs Code.: 2933990090
• Mol file: 124730-56-9.mol

Synonyms:4H-PYRROLO[3,2,1-IJ]QUINOLINE-1-CARBOXYLIC ACID,5,6-DIHYDRO-;5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1-carboxylic acid;2,3-Dihydro-1H-pyrrolo[3,2,1-ij]quinoline-6-carboxylic acid

Chemical Property of 4H-PYRROLO[3,2,1-IJ]QUINOLINE-1-CARBOXYLIC ACID,5,6-DIHYDRO-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 460.523°C at 760 mmHg
• Flash Point: 232.316°C
• PSA: 42.23000
• Density: 1.38
• LogP: 2.28570

Purity/Quality:

98%,99%, ^*data from raw suppliers

5,6-Dihydro-4H-pyrrolo[3,2,1-ij]-quinoline-1-carboxylic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-PYRROLO[3,2,1-IJ]QUINOLINE-1-CARBOXYLIC ACID,5,6-DIHYDRO-

There total 3 articles about 4H-PYRROLO[3,2,1-IJ]QUINOLINE-1-CARBOXYLIC ACID,5,6-DIHYDRO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5,6-dihydro-4H-pyrrolo [3,2,1-ij]quinoline-1-carboxylic acid ethyl ester (124730-53-6) → 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1-carboxylic acid (124730-56-9)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h; Heating;

DOI:10.1021/jm00075a026

Reference yield:

1,2,3,4-tetrahydroisoquinoline (635-46-1) → 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1-carboxylic acid (124730-56-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 24 h / Ambient temperature

2: MgCl₂ / 2-methoxy-ethanol; tetrahydrofuran / 6 h / 125 °C

3: 94 percent / aq. NaOH / ethanol / 2 h / Heating

With sodium hydroxide; magnesium chloride; In tetrahydrofuran; ethanol; 2-methoxy-ethanol;

DOI:10.1021/jm00075a026

Reference yield:

3-(3,4-dihydro-2H-quinolin-1-yl)-2-oxopropionic acid ethyl ester (152712-44-2) → 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1-carboxylic acid (124730-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1: MgCl₂ / 2-methoxy-ethanol; tetrahydrofuran / 6 h / 125 °C

2: 94 percent / aq. NaOH / ethanol / 2 h / Heating

With sodium hydroxide; magnesium chloride; In tetrahydrofuran; ethanol; 2-methoxy-ethanol;

DOI:10.1021/jm00075a026

upstream raw materials:

5,6-dihydro-4H-pyrrolo [3,2,1-ij]quinoline-1-carboxylic acid ethyl ester

1,2,3,4-tetrahydroisoquinoline

3-(3,4-dihydro-2H-quinolin-1-yl)-2-oxopropionic acid ethyl ester

Downstream raw materials:

3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(3-methoxyphenyl)pyrrole-2,5-dione

(±)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

(±)-cis-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dion

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