1,4-Cyclohexadiene-1,2-dicarboxylic acid, 3-[(acetyloxy)methyl]-5-[2-[(2,2-dimethyl-1-oxopropyl)amino]-3-methoxy- 3-oxopropyl]-, dimethyl ester

Base Information

Chemical Name:1,4-Cyclohexadiene-1,2-dicarboxylic acid, 3-[(acetyloxy)methyl]-5-[2-[(2,2-dimethyl-1-oxopropyl)amino]-3-methoxy- 3-oxopropyl]-, dimethyl ester
CAS No.:499797-04-5
Molecular Formula:C22H31NO9
Molecular Weight:453.489
Hs Code.:

1,4-Cyclohexadiene-1,2-dicarboxylic acid,
3-[(acetyloxy)methyl]-5-[2-[(2,2-dimethyl-1-oxopropyl)amino]-3-methoxy-
3-oxopropyl]-, dimethyl ester

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Chemical Property of 1,4-Cyclohexadiene-1,2-dicarboxylic acid, 3-[(acetyloxy)methyl]-5-[2-[(2,2-dimethyl-1-oxopropyl)amino]-3-methoxy- 3-oxopropyl]-, dimethyl ester

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Technology Process of 1,4-Cyclohexadiene-1,2-dicarboxylic acid, 3-[(acetyloxy)methyl]-5-[2-[(2,2-dimethyl-1-oxopropyl)amino]-3-methoxy- 3-oxopropyl]-, dimethyl ester

There total 5 articles about 1,4-Cyclohexadiene-1,2-dicarboxylic acid, 3-[(acetyloxy)methyl]-5-[2-[(2,2-dimethyl-1-oxopropyl)amino]-3-methoxy- 3-oxopropyl]-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 762-42-5
dimethyl acetylenedicarboxylate

: 290367-41-8
(E/Z)-7-acetoxy-2-(2,2-dimethylpropionylamino)-4-methylenehept-5-enoic acid methyl ester

: 499797-04-5
3-acetoxymethyl-5-[2-(2,2-dimethyl-propionylamino)-2-methoxycarbonyl-ethyl]-cyclohexa-1,4-diene-1,2-dicarboxylic acid dimethyl ester

Guidance literature:: In toluene; at 110 ℃; for 42h;
DOI:10.1016/S0040-4020(02)01178-X

Reference yield:

: 70837-20-6
propargyclycine methyl ester hydrochloride

: 499797-04-5
3-acetoxymethyl-5-[2-(2,2-dimethyl-propionylamino)-2-methoxycarbonyl-ethyl]-cyclohexa-1,4-diene-1,2-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

2: 47 percent / RuCl₂(CHC₆H₅)PCy₃ / benzene / 60 h / Heating

3: 62 percent / toluene / 42 h / 110 °C

With triethylamine; Grubbs catalyst first generation; In dichloromethane; toluene; benzene; 3: Diels-Alder reaction;
DOI:10.1016/S0040-4020(02)01178-X

Reference yield:

: 167904-79-2
methyl (R,S)-2-(N-diphenylmethylidene)aminopent-4-ynoate

: 499797-04-5
3-acetoxymethyl-5-[2-(2,2-dimethyl-propionylamino)-2-methoxycarbonyl-ethyl]-cyclohexa-1,4-diene-1,2-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / 1N HCl / diethyl ether / 24 h / 20 °C

2: 87 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

3: 47 percent / RuCl₂(CHC₆H₅)PCy₃ / benzene / 60 h / Heating

4: 62 percent / toluene / 42 h / 110 °C

With hydrogenchloride; triethylamine; Grubbs catalyst first generation; In diethyl ether; dichloromethane; toluene; benzene; 4: Diels-Alder reaction;
DOI:10.1016/S0040-4020(02)01178-X