Benzamide, 4-chloro-N-[2-(1H-indol-3-yl)-3-thienyl]-

Base Information

Chemical Name:Benzamide, 4-chloro-N-[2-(1H-indol-3-yl)-3-thienyl]-
CAS No.:500022-51-5
Molecular Formula:C₁₉H₁₃ClN₂OS
Molecular Weight:352.844
Hs Code.:
DSSTox Substance ID:DTXSID60476267
Nikkaji Number:J1.790.173G

Synonyms:500022-51-5;N-(2-(1H-Indol-3-yl)thiophen-3-yl)-4-chlorobenzamide;Benzamide, 4-chloro-N-[2-(1H-indol-3-yl)-3-thienyl]-;DTXSID60476267

Suppliers and Price of Benzamide, 4-chloro-N-[2-(1H-indol-3-yl)-3-thienyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzamide, 4-chloro-N-[2-(1H-indol-3-yl)-3-thienyl]-

Chemical Property:

XLogP3:4.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:352.0437119
Heavy Atom Count:24
Complexity:455

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=CN2)C3=C(C=CS3)NC(=O)C4=CC=C(C=C4)Cl

Technology Process of Benzamide, 4-chloro-N-[2-(1H-indol-3-yl)-3-thienyl]-

There total 3 articles about Benzamide, 4-chloro-N-[2-(1H-indol-3-yl)-3-thienyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 122-01-0
4-chloro-benzoyl chloride

: 500022-50-4
3-(3-aminothien-2-yl)indole

: 500022-51-5
3-[3-(4'-chlorobenzoyl)aminothien-2-yl]indole

Guidance literature:: With triethylamine; In benzene; for 4h; Heating;
DOI:10.3987/com-02-9551

Reference yield:

: 120-72-9
indole

: 500022-51-5
3-[3-(4'-chlorobenzoyl)aminothien-2-yl]indole

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / methylmagnesium iodide; ZnCl₂ / diethyl ether / 7 h / 20 °C

2: 74 percent / Sn; HCl / ethanol; H₂O / 2 h / Heating

3: 64 percent / Et₃N / benzene / 4 h / Heating

With hydrogenchloride; tin; methyl magnesium iodide; triethylamine; zinc(II) chloride; In diethyl ether; ethanol; water; benzene;
DOI:10.3987/com-02-9551

Reference yield:

: 500022-49-1
3-(3-nitrothien-2-yl)indole

: 500022-51-5
3-[3-(4'-chlorobenzoyl)aminothien-2-yl]indole

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / Sn; HCl / ethanol; H₂O / 2 h / Heating

2: 64 percent / Et₃N / benzene / 4 h / Heating

With hydrogenchloride; tin; triethylamine; In ethanol; water; benzene;
DOI:10.3987/com-02-9551