5,8-Dihydroxy-6,7-dimethoxyflavone

Base Information

• Chemical Name: 5,8-Dihydroxy-6,7-dimethoxyflavone
• CAS No.: 73202-52-5
• Molecular Formula: C17H14O6
• Molecular Weight: 314.295
• DSSTox Substance ID: DTXSID20223451
• Nikkaji Number: J573.047C
• Wikidata: Q83101897
• Metabolomics Workbench ID: 24514
• Mol file: 73202-52-5.mol

Synonyms:5,8-Dihydroxy-6,7-dimethoxyflavone;73202-52-5;6,7-Dimethoxy-5,8-dihydroxy flavone;5,8-dihydroxy-6,7-dimethoxy-2-phenylchromen-4-one;SCHEMBL8160531;DTXSID20223451;LMPK12111431;5,8-Dihydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one

Chemical Property of 5,8-Dihydroxy-6,7-dimethoxyflavone

Chemical Property:

• Vapor Pressure: 1.13E-13mmHg at 25°C
• Boiling Point: 571.7°C at 760 mmHg
• Flash Point: 214.8°C
• Density: 1.402g/cm³
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 314.07903816
• Heavy Atom Count: 23
• Complexity: 470

Purity/Quality:

≥98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=C2C(=C1O)C(=O)C=C(O2)C3=CC=CC=C3)O)OC

Technology Process of 5,8-Dihydroxy-6,7-dimethoxyflavone

There total 3 articles about 5,8-Dihydroxy-6,7-dimethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

8-benzyloxy-5-hydroxy-6,7-dimethoxyflavone (169130-05-6) → 5,8-dihydroxy-6,7-dimethoxyflavone (73202-52-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate;

DOI:10.1016/0031-9422(95)00070-N

Reference yield: 12.0%

mosloflavone (740-33-0) → 5,8-dihydroxy-6,7-dimethoxyflavone (73202-52-5)

Guidance literature:

With sodium hydroxide; potassium peroxomonosulphate; In water; at 15 - 20 ℃;

DOI:10.1271/bbb.68.369

Reference yield:

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one (491-67-8) → 5,8-dihydroxy-6,7-dimethoxyflavone (73202-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; acetone

2: pyridine; aqueous KOH-solution; aqueous potassium peroxo disulfate solution / anschliessendes Erwaermen mit Natriumsulfit und wss. Salzsaeure

With pyridine; potassium hydroxide; dipotassium peroxodisulfate; potassium carbonate; acetone;

upstream raw materials:

mosloflavone

8-benzyloxy-5-hydroxy-6,7-dimethoxyflavone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Downstream raw materials:

5,8-diacetoxy-6,7-dimethoxy-2-phenyl-chromen-4-one

5,6,7,8-tetrahydroxyflavone tetramethyl ether

5,6,7,8-tetrahydroxyflavone