MOSLOFLAVONE

Base Information

• Chemical Name: MOSLOFLAVONE
• CAS No.: 740-33-0
• Molecular Formula: C17H14O5
• Molecular Weight: 298.295
• Hs Code.: 2914509090
• Mol file: 740-33-0.mol

Synonyms:5-hydroxy-6,7-dimethoxy-2-phenylchromen-4-one;

Chemical Property of MOSLOFLAVONE

Chemical Property:

• Vapor Pressure: 5.81E-11mmHg at 25°C
• Melting Point: 163-164oC (chloroform , acetone )
• Boiling Point: 508.5oC at 760 mmHg
• PKA: 6.32±0.40(Predicted)
• Flash Point: 190.5oC
• PSA: 68.90000
• Density: 1.321g/cm3
• LogP: 3.18280
• Storage Temp.: 2-8°C

Purity/Quality:

≥98% ^*data from raw suppliers

5-Hydroxy-6,7-dimethoxylflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MOSLOFLAVONE

There total 18 articles about MOSLOFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5,6,7-trimethoxyflavone (973-67-1) → mosloflavone (740-33-0)

Guidance literature:

With boron trichloride; In dichloromethane; at 0 ℃; for 0.5h; regioselective reaction;

DOI:10.1002/hlca.201100162

Reference yield: 93.4%

C18H13BrO5 (1215208-44-8) + sodium methylate (124-41-4) → mosloflavone (740-33-0)

Guidance literature:

sodium methylate; With copper(I) bromide; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 1h;

C₁₈H₁₃BrO₅; In methanol; N,N-dimethyl-formamide; at 120 ℃; for 0.666667h;

With hydrogenchloride; In methanol; water; N,N-dimethyl-formamide; at 20 ℃; Cooling;

DOI:10.1016/j.tet.2009.12.021

Reference yield: 82.0%

methanol (67-56-1) + tectochrysine (520-28-5) + sodium methylate (124-41-4) → mosloflavone (740-33-0)

Guidance literature:

tectochrysine; With tetra-N-butylammonium tribromide; In chloroform; at 20 ℃; for 2h;

methanol; sodium methylate; With copper(I) bromide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

In N,N-dimethyl-formamide; at 120 ℃; for 5h; regiospecific reaction;

DOI:10.3390/molecules24142553

upstream raw materials:

diazomethane

oroxylin A

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

dimethyl sulfate

Downstream raw materials:

5-acetoxy-6,7-dimethoxyflavone

5,6-dihydroxy-7-methoxyflavone

5,6,7,8-tetrahydroxyflavone

5,6,7-trihydroxy-8-methylflavone

Refernces

• 1、 -. "PROCESS FOR SYNTHESIS OF OROXYLIN A". Page/Page column 7-9. . Retrieved 2020/03/02.
• 2、 Moreira, Joana,Ribeiro, Diana,Silva, Patrícia M. A.,Nazareth, Nair,Monteiro, Madalena,Palmeira, Andreia,Saraiva, Lucília,Pinto, Madalena,Bousbaa, Hassan,Cidade, Honorina. "New alkoxy flavone derivatives targeting caspases: Synthesis and antitumor activity evaluation". . . Retrieved 2019/01/14.