2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-3-[[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]carb onyl]-, 1,1-dimethylethyl ester, (3S)-

Base Information

Chemical Name:2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-3-[[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]carb onyl]-, 1,1-dimethylethyl ester, (3S)-
CAS No.:500213-34-3
Molecular Formula:C25H30N2O5
Molecular Weight:438.524
Hs Code.:
Mol file:500213-34-3.mol

2(1H)-Isoquinolinecarboxylic acid,
3,4-dihydro-3-[[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]carb
onyl]-, 1,1-dimethylethyl ester, (3S)-

Synonyms:

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Chemical Property of 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-3-[[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]carb onyl]-, 1,1-dimethylethyl ester, (3S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-3-[[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]carb onyl]-, 1,1-dimethylethyl ester, (3S)-

There total 4 articles about 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-3-[[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]carb onyl]-, 1,1-dimethylethyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 115962-35-1,144069-68-1,78879-20-6
(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid

: 500213-34-3
(S)-tert-butyl 3-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

methyl (2S)-2-amino-3-phenylpropanoate; With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2010.12.005

Reference yield: 87.0%

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 115962-35-1,144069-68-1,78879-20-6
(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid

: 500213-34-3
(S)-tert-butyl 3-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; under 750.075 Torr; Inert atmosphere;

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride; With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃; for 12h; under 750.075 Torr; Inert atmosphere;
DOI:10.1016/j.ejmech.2009.08.002

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 500213-34-3
(S)-tert-butyl 3-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / chloroform; water / 10 h / 80 - 90 °C

2.1: sodium hydroxide / tetrahydrofuran; water / 48 h / 20 °C

3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 0 °C

3.2: 12 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; chloroform; water;
DOI:10.1016/j.bmc.2010.12.005