2-Propenoic acid, 3-[6-[[(2R,3S)-5-oxo-2-(phenylseleno)-3-[(triethylsilyl)oxy]-1-pyrrolidinyl] methyl]-1,3-benzodioxol-5-yl]-, 1,1-dimethylethyl ester, (2E)-

Base Information

Chemical Name:2-Propenoic acid, 3-[6-[[(2R,3S)-5-oxo-2-(phenylseleno)-3-[(triethylsilyl)oxy]-1-pyrrolidinyl] methyl]-1,3-benzodioxol-5-yl]-, 1,1-dimethylethyl ester, (2E)-
CAS No.:500213-41-2
Molecular Formula:C31H41NO6SeSi
Molecular Weight:630.715
Hs Code.:

2-Propenoic acid,
3-[6-[[(2R,3S)-5-oxo-2-(phenylseleno)-3-[(triethylsilyl)oxy]-1-pyrrolidinyl]
methyl]-1,3-benzodioxol-5-yl]-, 1,1-dimethylethyl ester, (2E)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propenoic acid, 3-[6-[[(2R,3S)-5-oxo-2-(phenylseleno)-3-[(triethylsilyl)oxy]-1-pyrrolidinyl] methyl]-1,3-benzodioxol-5-yl]-, 1,1-dimethylethyl ester, (2E)-

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Technology Process of 2-Propenoic acid, 3-[6-[[(2R,3S)-5-oxo-2-(phenylseleno)-3-[(triethylsilyl)oxy]-1-pyrrolidinyl] methyl]-1,3-benzodioxol-5-yl]-, 1,1-dimethylethyl ester, (2E)-

There total 4 articles about 2-Propenoic acid, 3-[6-[[(2R,3S)-5-oxo-2-(phenylseleno)-3-[(triethylsilyl)oxy]-1-pyrrolidinyl] methyl]-1,3-benzodioxol-5-yl]-, 1,1-dimethylethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 994-30-9
triethylsilyl chloride

: 500213-39-8
(4S,5R)-(E)-N-(2-tert-butoxycarbonylethenyl-4,5-methylenedioxybenzyl)-4-hydroxy-5-phenylselenyl-2-pyrrolidinone

: 500213-41-2
(4S,5R)-(E)-N-[2-(tert-butoxycarbonylethenyl)-4,5-methylenedioxybenzyl]-4-triethylsilyloxy-5-phenylselenylpyrrolidin-2-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.3987/COM-02-9610

Reference yield:

: 69048-76-6
6-iodo-1,3-benzodioxole-5-methanol

: 500213-41-2
(4S,5R)-(E)-N-[2-(tert-butoxycarbonylethenyl)-4,5-methylenedioxybenzyl]-4-triethylsilyloxy-5-phenylselenylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / PPh₃; DEAD / tetrahydrofuran / 1 h / 20 °C

2.1: NaBH₄ / ethanol; tetrahydrofuran / 1.5 h / 0 °C

2.2: 67 percent / p-TsOH*H₂O / CH₂Cl₂ / 2 h / 20 °C

3.1: 62 percent / Pd(OAc)3; PPh₃; Et₃N / various solvent(s) / 9 h / 100 °C

4.1: 54 percent / imidazole / dimethylformamide / 2 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; palladium(III) acetate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 3.1: Heck reaction;
DOI:10.3987/COM-02-9610

Reference yield:

: 244260-64-8
(3S)-3-acetoxy-N-(2-iodo-4,5-methylenedioxybenzyl)-2,5-pyrrolidinedione

: 500213-41-2
(4S,5R)-(E)-N-[2-(tert-butoxycarbonylethenyl)-4,5-methylenedioxybenzyl]-4-triethylsilyloxy-5-phenylselenylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaBH₄ / ethanol; tetrahydrofuran / 1.5 h / 0 °C

1.2: 67 percent / p-TsOH*H₂O / CH₂Cl₂ / 2 h / 20 °C

2.1: 62 percent / Pd(OAc)3; PPh₃; Et₃N / various solvent(s) / 9 h / 100 °C

3.1: 54 percent / imidazole / dimethylformamide / 2 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; palladium(III) acetate; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 2.1: Heck reaction;
DOI:10.3987/COM-02-9610