L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-(2S)-2-piperidinecarbonyl- L-phenylalanyl-L-tryptophyl-(2S)-2-piperidinecarbonyl-, methyl ester

Base Information

Chemical Name:L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-(2S)-2-piperidinecarbonyl- L-phenylalanyl-L-tryptophyl-(2S)-2-piperidinecarbonyl-, methyl ester
CAS No.:500213-61-6
Molecular Formula:C₅₈H₆₈N₈O₉
Molecular Weight:1021.23
Hs Code.:

L-Phenylalanine,
N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-(2S)-2-piperidinecarbonyl-
L-phenylalanyl-L-tryptophyl-(2S)-2-piperidinecarbonyl-, methyl ester

Synonyms:

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Chemical Property of L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-(2S)-2-piperidinecarbonyl- L-phenylalanyl-L-tryptophyl-(2S)-2-piperidinecarbonyl-, methyl ester

Chemical Property:

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Technology Process of L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-(2S)-2-piperidinecarbonyl- L-phenylalanyl-L-tryptophyl-(2S)-2-piperidinecarbonyl-, methyl ester

There total 7 articles about L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-(2S)-2-piperidinecarbonyl- L-phenylalanyl-L-tryptophyl-(2S)-2-piperidinecarbonyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 500213-61-6
(S)-2-({(S)-1-[(S)-2-[(S)-2-({(S)-1-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-piperidine-2-carbonyl}-amino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionyl]-piperidine-2-carbonyl}-amino)-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: [O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium]PF₆; 4-(dimethylamino)pyridine; Hunig's base / CH₂Cl₂

2: TFA; anisole / CH₂Cl₂

3: [O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium]PF₆; 4-(dimethylamino)pyridine; Hunig's base / CH₂Cl₂

4: TFA; anisole / CH₂Cl₂

5: [O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium]PF₆; 4-(dimethylamino)pyridine; Hunig's base / CH₂Cl₂

With dmap; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ol020204f

Reference yield:

: 13139-14-5
Boc-Trp-OH

: 500213-61-6
(S)-2-({(S)-1-[(S)-2-[(S)-2-({(S)-1-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-piperidine-2-carbonyl}-amino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionyl]-piperidine-2-carbonyl}-amino)-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: [O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium]PF₆; 4-(dimethylamino)pyridine; Hunig's base / CH₂Cl₂

2: TFA; anisole / CH₂Cl₂

3: [O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium]PF₆; 4-(dimethylamino)pyridine; Hunig's base / CH₂Cl₂

With dmap; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ol020204f

Reference yield:

: 26250-84-0
(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

: 500213-61-6
(S)-2-({(S)-1-[(S)-2-[(S)-2-({(S)-1-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-piperidine-2-carbonyl}-amino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionyl]-piperidine-2-carbonyl}-amino)-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: [O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium]PF₆; 4-(dimethylamino)pyridine; Hunig's base / CH₂Cl₂

2: TFA; anisole / CH₂Cl₂

3: [O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium]PF₆; 4-(dimethylamino)pyridine; Hunig's base / CH₂Cl₂

4: TFA; anisole / CH₂Cl₂

5: [O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium]PF₆; 4-(dimethylamino)pyridine; Hunig's base / CH₂Cl₂

With dmap; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ol020204f