4H-1,3-Benzodioxin-2-carboxylic acid, 6-chloro-4-methyl-4-phenyl-, 2-(dimethylamino)ethyl ester, hydrochloride, trans-

Base Information

Chemical Name:4H-1,3-Benzodioxin-2-carboxylic acid, 6-chloro-4-methyl-4-phenyl-, 2-(dimethylamino)ethyl ester, hydrochloride, trans-
CAS No.:86616-87-7
Molecular Formula:C₂₀H₂₂ClNO₄*ClH
Molecular Weight:412.313
Hs Code.:
DSSTox Substance ID:DTXSID60235699

Synonyms:4H-1,3-Benzodioxin-2-carboxylic acid, 6-chloro-4-methyl-4-phenyl-, 2-(dimethylamino)ethyl ester, hydrochloride, trans-;86616-87-7;C20H22ClNO4.ClH;DTXSID60235699;C20-H22-Cl-N-O4.Cl-H;LS-34562

Suppliers and Price of 4H-1,3-Benzodioxin-2-carboxylic acid, 6-chloro-4-methyl-4-phenyl-, 2-(dimethylamino)ethyl ester, hydrochloride, trans-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4H-1,3-Benzodioxin-2-carboxylic acid, 6-chloro-4-methyl-4-phenyl-, 2-(dimethylamino)ethyl ester, hydrochloride, trans-

Chemical Property:

Vapor Pressure:7.36E-10mmHg at 25°C
Boiling Point:492.9°C at 760 mmHg
Flash Point:251.9°C
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:411.1004136
Heavy Atom Count:27
Complexity:482

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C2=C(C=CC(=C2)Cl)OC(O1)C(=O)OCCN(C)C)C3=CC=CC=C3.Cl
Isomeric SMILES:C[C@@]1(C2=C(C=CC(=C2)Cl)O[C@@H](O1)C(=O)OCCN(C)C)C3=CC=CC=C3.Cl

Technology Process of 4H-1,3-Benzodioxin-2-carboxylic acid, 6-chloro-4-methyl-4-phenyl-, 2-(dimethylamino)ethyl ester, hydrochloride, trans-

There total 6 articles about 4H-1,3-Benzodioxin-2-carboxylic acid, 6-chloro-4-methyl-4-phenyl-, 2-(dimethylamino)ethyl ester, hydrochloride, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67059-77-2
acide benzodioxine-(1,3)> caboxylique-2

: 74271-50-4,86616-87-7
(2R,4R)-6-Chloro-4-methyl-4-phenyl-4H-benzo[1,3]dioxine-2-carboxylic acid 2-dimethylamino-ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1 g / CH₂Cl₂ / 24 h

2: 81.5 percent / KOH / H₂O; methanol / 24 h / Ambient temperature

With potassium hydroxide; In methanol; dichloromethane; water;

Reference yield:

: 85-19-8
(5-chloro-2-hydroxyphenyl)phenylmethanone

: 74271-50-4,86616-87-7
(2R,4R)-6-Chloro-4-methyl-4-phenyl-4H-benzo[1,3]dioxine-2-carboxylic acid 2-dimethylamino-ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / benzene; diethyl ether / 2 h / Heating

2: 50percent NaH/mineral oil, 18 crown 6 / dioxane / 3 h / 65 °C

With 18-crown-6 ether; sodium hydride; mineral oil; In 1,4-dioxane; diethyl ether; benzene;

Reference yield:

: 74271-47-9
chloro-5 hydroxy-2 α-methyl α-phenyl benzene methanol

: 74271-50-4,86616-87-7
(2R,4R)-6-Chloro-4-methyl-4-phenyl-4H-benzo[1,3]dioxine-2-carboxylic acid 2-dimethylamino-ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 50percent NaH/mineral oil, 18 crown 6 / dioxane / 3 h / 65 °C

With 18-crown-6 ether; sodium hydride; mineral oil; In 1,4-dioxane;