Tert-butyl 3-(methylsulfonyloxymethyl)-2,3-dihydroindole-1-carboxylate

Base Information

Chemical Name:Tert-butyl 3-(methylsulfonyloxymethyl)-2,3-dihydroindole-1-carboxylate
CAS No.:130469-60-2
Molecular Formula:C₁₅H₂₁NO₅S
Molecular Weight:327.401
Hs Code.:
DSSTox Substance ID:DTXSID00926751
Mol file:130469-60-2.mol

Synonyms:130469-60-2;Tert-butyl 3-(methylsulfonyloxymethyl)-2,3-dihydroindole-1-carboxylate;DTXSID00926751;(+/-)-2,3-Dihydro-3-(((methylsulfonyl)oxy)methyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester;tert-Butyl 3-{[(methanesulfonyl)oxy]methyl}-2,3-dihydro-1H-indole-1-carboxylate

Suppliers and Price of Tert-butyl 3-(methylsulfonyloxymethyl)-2,3-dihydroindole-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Tert-butyl 3-(methylsulfonyloxymethyl)-2,3-dihydroindole-1-carboxylate

Chemical Property:

Vapor Pressure:1.86E-08mmHg at 25°C
Boiling Point:454.8°Cat760mmHg
Flash Point:228.8°C
PSA：81.29000
Density:1.25g/cm³
LogP:3.64730
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:327.11404394
Heavy Atom Count:22
Complexity:505

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC(C2=CC=CC=C21)COS(=O)(=O)C

Technology Process of Tert-butyl 3-(methylsulfonyloxymethyl)-2,3-dihydroindole-1-carboxylate

There total 8 articles about Tert-butyl 3-(methylsulfonyloxymethyl)-2,3-dihydroindole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 115444-91-2
methanesulfonic acid 3-methanesulfonyloxy-2-(2-nitrophenyl)-propyl ester

: 130469-60-2
1-(tert-Butyloxycarbonyl)-3-(methanesulfonyloxymethyl)indoline

Guidance literature:: With palladium on activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2021.116167

Reference yield:

: 161646-52-2
1-(tert-Butyloxycarbonyl)-3-(hydroxymethyl)-2,3-dihydroindole

: 124-63-0
methanesulfonyl chloride

: 130469-60-2
1-(tert-Butyloxycarbonyl)-3-(methanesulfonyloxymethyl)indoline

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 8h; Yield given;
DOI:10.1016/S0040-4020(01)81798-1

Reference yield:

: 34619-03-9
tert-butyldicarbonate

: 130469-60-2
1-(tert-Butyloxycarbonyl)-3-(methanesulfonyloxymethyl)indoline

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 h / 23 °C

2: triethylamine / CH₂Cl₂ / 8 h / 0 °C

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)81798-1