Technology Process of 2-Propenoic acid,
3-[(1S,2S)-4-[(4S,5S)-2,2-dimethyl-5-(3-oxopropyl)-1,3-dioxolan-4-yl]-1-
(3-oxopropyl)-2-(phenylmethoxy)butoxy]-, ethyl ester, (2E)-
There total 8 articles about 2-Propenoic acid,
3-[(1S,2S)-4-[(4S,5S)-2,2-dimethyl-5-(3-oxopropyl)-1,3-dioxolan-4-yl]-1-
(3-oxopropyl)-2-(phenylmethoxy)butoxy]-, ethyl ester, (2E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate; methyl iodide;
In
acetonitrile;
at 20 ℃;
for 35h;
DOI:10.1002/anie.200290038
- Guidance literature:
-
Multi-step reaction with 7 steps
1: AD-mix-α; MeSO2NH2; H2O / 2-methyl-propan-2-ol / 24 h / 0 °C
2: 10-camphorsulfonic acid / methanol / 3 h / -5 °C
3: 93 percent / NaH / tetrahydrofuran / 16 h / -15 - 20 °C
4: Zn(OTf)2 / 1,2-dichloro-ethane / 2 h / 50 °C
5: 10-camphorsulfonic acid / CH2Cl2 / 1 h / 20 °C
6: N-methylmorpholine / CH2Cl2 / 5 h / 20 °C
7: MeI; aq. NaHCO3 / acetonitrile / 35 h / 20 °C
With
4-methyl-morpholine; AD-mix-α; methanesulfonamide; (1S)-10-camphorsulfonic acid; water; zinc trifluoromethanesulfonate; sodium hydride; sodium hydrogencarbonate; methyl iodide;
In
tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;
1: Sharpless dihydroxylation / 6: hetero-Michael addition;
DOI:10.1002/anie.200290038
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 99 percent / 10-camphorsulfonic acid / methanol / 1 h / 20 °C
2: AD-mix-α; MeSO2NH2; H2O / 2-methyl-propan-2-ol / 24 h / 0 °C
3: 10-camphorsulfonic acid / methanol / 3 h / -5 °C
4: 93 percent / NaH / tetrahydrofuran / 16 h / -15 - 20 °C
5: Zn(OTf)2 / 1,2-dichloro-ethane / 2 h / 50 °C
6: 10-camphorsulfonic acid / CH2Cl2 / 1 h / 20 °C
7: N-methylmorpholine / CH2Cl2 / 5 h / 20 °C
8: MeI; aq. NaHCO3 / acetonitrile / 35 h / 20 °C
With
4-methyl-morpholine; AD-mix-α; methanesulfonamide; (1S)-10-camphorsulfonic acid; water; zinc trifluoromethanesulfonate; sodium hydride; sodium hydrogencarbonate; methyl iodide;
In
tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;
2: Sharpless dihydroxylation / 7: hetero-Michael addition;
DOI:10.1002/anie.200290038
![(E)-3-{(1S,2S)-2-Benzyloxy-1-(2-[1,3]dithian-2-yl-ethyl)-4-[(4S,5S)-5-(2-[1,3]dithian-2-yl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-butoxy}-acrylic acid ethyl ester](/Databaselist/images/loading.webp)
