2,6-Dibromostyrene

Base Information

• Chemical Name: 2,6-Dibromostyrene
• CAS No.: 500761-44-4
• Molecular Formula: C8H6Br2
• Molecular Weight: 261.944
• UNII: 751E78060C
• Nikkaji Number: J455.489B
• Mol file: 500761-44-4.mol

Synonyms:2,6-dibromostyrene;1,3-Dibromo-2-vinylbenzene;Benzene, 1,3-dibromo-2-ethenyl-;J455.489B;751E78060C;UNII-751E78060C;500761-44-4;SCHEMBL320296;1,3-dibromo-2-ethenylbenzene;EN300-1939192

Chemical Property of 2,6-Dibromostyrene

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 1
• Exact Mass: 261.88158
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C=CC1=C(C=CC=C1Br)Br

Technology Process of 2,6-Dibromostyrene

There total 2 articles about 2,6-Dibromostyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dibromobenzaldehyde (67713-23-9) + methyl-triphenylphosphonium iodide (2065-66-9) → 2,6-dibromostyrene (500761-44-4)

Guidance literature:

methyl-triphenylphosphonium iodide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃;

2,6-dibromobenzaldehyde; In tetrahydrofuran; Reflux;

DOI:10.1021/ol802816k

Reference yield:

2,6-dibromobenzyl bromide (93701-32-7) → 2,6-dibromostyrene (500761-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 5.1 g / benzene / 5 h / 50 °C

2: 36 percent / aq. NaOH / 1 h

With sodium hydroxide; In benzene; 2: Wittig reaction;

DOI:10.1039/b203891a

Reference yield: 48.0%

oxalic acid diethyl ester (95-92-1) + 2,6-dibromostyrene (500761-44-4) → ethyl 2-(3-bromo-2-vinylphenyl)-2-hydroxyacetate (1111310-74-7)

Guidance literature:

2,6-dibromostyrene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

oxalic acid diethyl ester; In tetrahydrofuran; diethyl ether; hexane; at -78 ℃;

With sodium cyanoborohydride; In ethanol; water; acetic acid; at 20 ℃;

DOI:10.1021/ol802816k

upstream raw materials:

2,6-dibromobenzyl bromide

2,6-dibromobenzaldehyde

methyl-triphenylphosphonium iodide

Downstream raw materials:

ethyl 2-(3-bromo-2-vinylphenyl)-2-hydroxyacetate

ethyl 2-(3-bromo-2-vinylphenyl)-2-(methylsulfonyloxy)acetate