93701-32-7

Basic information

• Product Name: 1,3-DibroMo-2-(broMoMethyl)benzene
• Synonyms: 1,3-DibroMo-2-(broMoMethyl)benzene;2,6-Dibromobenzyl bromide
• CAS NO: 93701-32-7
• Molecular Formula: C₇H₅Br₃
• Molecular Weight: 328.8266
• Mol File: 93701-32-7.mol
• Article Data: 22

Chemical Properties

• Melting Point: 80-81 °C(Solv: hexane (110-54-3))
• Boiling Point: 306.3°C at 760 mmHg
• Flash Point: 136.5°C
• Appearance: /
• Density: 2.173g/cm³
• Vapor Pressure: 0.00141mmHg at 25°C
• Refractive Index: 1.636
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,3-DibroMo-2-(broMoMethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DibroMo-2-(broMoMethyl)benzene(93701-32-7)
• EPA Substance Registry System: 1,3-DibroMo-2-(broMoMethyl)benzene(93701-32-7)

Safety Data

• Hazardous Substances Data: 93701-32-7(Hazardous Substances Data)

Usage

Uses

2,6-Dibromobenzyl Bromide is used in preparation of Indoles via tBuOK-promoted cyclization of Imines with Aryl Halides. Also, used in preparation of 1,2,3,4-Tetrahydro-1,8-naphthyridine derivatives as inhibitors of αvβ6 integrin.

InChI:InChI=1/C7H5Br3/c8-4-5-6(9)2-1-3-7(5)10/h1-3H,4H2

Upstream product

• 69321-60-4 2,6-dibromotoluene 
• 601-84-3 2,6-dibromobenzoic acid 

Downstream Products

• 1013031-65-6 (2,6-dibromophenyl)methanol 
• 256651-54-4 C₉H₈Br₂OS 
• 1147858-83-0 acetic acid 2,6-dibromobenzyl ester 
• 957211-35-7 2-(2,6-dibromo-benzyl)-malonic acid diethyl ester 
• 1380403-76-8 4-(2,6-dibromophenyl)-2-methylbutanal 
• 1380403-56-4 C₁₁H₁₄Br₂O 
• 1380403-48-4 C₁₁H₁₂Br₂ 
• 1178884-42-8 acetic acid 2-bromo-6-(6-dimethylamino-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)benzyl ester 
• 863870-92-2 4-bromo-2-phenylbenzo[b]furan 
• 67197-53-9 2-(2,6-dibromophenyl)acetonitrile 
• 500761-44-4 2,6-dibromostyrene 

Relevant articles and documents

KRAS G12C INHIBITORS

The present invention provides compounds of the formula: where R1, R2, R3, R4, R5, A, B, and Y are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer.

tBuOK-Promoted Cyclization of Imines with Aryl Halides

A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramolecular coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.

Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem C-H and C-O Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans

An intermolecular addition of carbon radicals enabled by a cascade radical coupling strategy is developed. It includes an intermolecular alkyl radical addition to a carbonyl group followed by an intramolecular alkoxy radical addition to haloarenes and produces substituted benzofurans in high yields. The radical nature of this reaction is explored by radical trapping experiments and EPR analysis. The mechanism is investigated by KIE experiments and control experiments. This method could provide rapid and practical access to the key intermediate of TAM-16, a safe and potent antibacterial agent for treating tuberculosis, and, therefore, is of great importance for organic synthesis and the pharmaceutical industry.