Silane, (difluoroacetyl)(1,1-dimethylethyl)diphenyl-

Base Information

• Chemical Name: Silane, (difluoroacetyl)(1,1-dimethylethyl)diphenyl-
• CAS No.: 500761-60-4
• Molecular Formula: C18H20F2OSi
• Molecular Weight: 318.439
• DSSTox Substance ID: DTXSID80467051
• Nikkaji Number: J1.760.636K
• Wikidata: Q82293824

Synonyms:Silane, (difluoroacetyl)(1,1-dimethylethyl)diphenyl-;500761-60-4;DTXSID80467051

Chemical Property of Silane, (difluoroacetyl)(1,1-dimethylethyl)diphenyl-

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 318.12514812
• Heavy Atom Count: 22
• Complexity: 359

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)C(F)F

Technology Process of Silane, (difluoroacetyl)(1,1-dimethylethyl)diphenyl-

There total 1 articles about Silane, (difluoroacetyl)(1,1-dimethylethyl)diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 1-(tert-butyldiphenylsilyl)-2,2-difluoroethanone (500761-60-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA; HMPA / tetrahydrofuran / 0 - 20 °C

2.1: water / tetrahydrofuran / 0.17 h / 20 °C

2.2: aq. HF / tetrahydrofuran / 0.5 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; water; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/jo049551o

Reference yield: 97.0%

allyl bromide (106-95-6) + 1-(tert-butyldiphenylsilyl)-2,2-difluoroethanone (500761-60-4) → 2-(tert-butyldiphenylsilanyl)-1,1-difluoro-4-penten-2-ol

Guidance literature:

With indium; In tetrahydrofuran; water; for 24h;

DOI:10.1016/j.tet.2003.10.033

Reference yield: 76.0%

allyl-trimethyl-silane (762-72-1) + 1-(tert-butyldiphenylsilyl)-2,2-difluoroethanone (500761-60-4) → 1-(tert-butyldiphenylsilyl)-1-fluoropent-4-en-2-one

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.jfluchem.2003.12.014

upstream raw materials:

tert-butylchlorodiphenylsilane

Downstream raw materials:

(1-difluoromethylvinyloxy)-tert-butyldiphenylsilane

1-(tert-butyldiphenylsilyl)-2-fluoroethanone

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