Technology Process of 1(2H)-Pyrazinecarboxylic acid,
3,4-dihydro-3-oxo-2-(phenylmethyl)-4-[3-[1-(triphenylmethyl)-1H-imidaz
ol-4-yl]-2-propenyl]-, phenylmethyl ester, (2S)-
There total 7 articles about 1(2H)-Pyrazinecarboxylic acid,
3,4-dihydro-3-oxo-2-(phenylmethyl)-4-[3-[1-(triphenylmethyl)-1H-imidaz
ol-4-yl]-2-propenyl]-, phenylmethyl ester, (2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran;
at 60 ℃;
for 2h;
DOI:10.1039/b517572k
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 75 percent / LiAlH4 / tetrahydrofuran
2: 75 percent / SOCl2 / tetrahydrofuran / 1 h
3: 21 percent / NaH / tetrahydrofuran / 2 h / 60 °C
With
lithium aluminium tetrahydride; thionyl chloride; sodium hydride;
In
tetrahydrofuran;
DOI:10.1039/b517572k
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 86 percent / EDCI; DIEA / CH2Cl2 / 5 h / 20 °C
2: 84 percent / TFA / H2O / 2 h / 20 °C
3: 21 percent / NaH / tetrahydrofuran / 2 h / 60 °C
With
sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1039/b517572k
