Propanoic acid, 3-[[2-(2-methoxyphenyl)ethyl]amino]-3-oxo-, ethyl ester

Base Information

Chemical Name:Propanoic acid, 3-[[2-(2-methoxyphenyl)ethyl]amino]-3-oxo-, ethyl ester
CAS No.:500869-15-8
Molecular Formula:C₁₄H₁₉NO₄
Molecular Weight:265.309
Hs Code.:
NSC Number:160560
DSSTox Substance ID:DTXSID00303725
Wikidata:Q82049170

Synonyms:500869-15-8;Propanoic acid, 3-[[2-(2-methoxyphenyl)ethyl]amino]-3-oxo-, ethyl ester;NSC160560;DTXSID00303725;NSC-160560

Suppliers and Price of Propanoic acid, 3-[[2-(2-methoxyphenyl)ethyl]amino]-3-oxo-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanoic acid, 3-[[2-(2-methoxyphenyl)ethyl]amino]-3-oxo-, ethyl ester

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:265.13140809
Heavy Atom Count:19
Complexity:293

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC(=O)NCCC1=CC=CC=C1OC

Technology Process of Propanoic acid, 3-[[2-(2-methoxyphenyl)ethyl]amino]-3-oxo-, ethyl ester

There total 1 articles about Propanoic acid, 3-[[2-(2-methoxyphenyl)ethyl]amino]-3-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36239-09-5
ethyl chlorocarbonylacetate

: 2045-79-6
o-methoxy-2-phenylethylamine

: 500869-15-8
N-[2-(2-methoxy-phenyl)-ethyl]-malonamic acid ethyl ester

Guidance literature:: With potassium carbonate; In dichloromethane; at 0 ℃;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 500869-15-8
N-[2-(2-methoxy-phenyl)-ethyl]-malonamic acid ethyl ester

: dimethylcarbamic acid 2-methyl-1-[2-(4-nitrophenoxy)ethyl]-1,2,3,4-tetrahydroisoquinolin-5-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: polyphosphate ester / 80 °C

2: H₂; acetic acid / PtO₂ / 20 °C

3: 111 mg / boron tribromide / CH₂Cl₂ / 3 h / 20 °C

4: 85 mg / formic acid / H₂O / 3 h / 80 °C

5: 59 percent / K₂CO₃ / dimethylformamide / 12 h / 20 °C

6: 86 percent / LiAlH₄ / tetrahydrofuran / 0.33 h / -20 °C

7: 39 percent / NaH / dimethylformamide / 0.5 h / 20 °C

With lithium aluminium tetrahydride; formic acid; polyphosphate ester; hydrogen; boron tribromide; sodium hydride; potassium carbonate; acetic acid; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1: Bischler-Napieralski reaction / 4: Eshweiler-Clarke reaction;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 500869-15-8
N-[2-(2-methoxy-phenyl)-ethyl]-malonamic acid ethyl ester

: 649722-35-0
(5-hydroxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: polyphosphate ester / 80 °C

2: H₂; acetic acid / PtO₂ / 20 °C

3: 111 mg / boron tribromide / CH₂Cl₂ / 3 h / 20 °C

With polyphosphate ester; hydrogen; boron tribromide; acetic acid; platinum(IV) oxide; In dichloromethane; 1: Bischler-Napieralski reaction;
DOI:10.1016/S0968-0896(03)00452-8