36239-09-5 Usage
Description
Ethyl malonyl chloride is an organic compound that serves as a key intermediate in various chemical reactions and synthesis processes. It is characterized by its reactivity and ability to form a wide range of products, making it a valuable component in the chemical industry.
Uses
Used in Pharmaceutical Industry:
Ethyl malonyl chloride is used as a versatile acylating agent for propargyl alcohols, hydrazines, and amines, which are essential in the synthesis of various pharmaceutical compounds.
Used in Chemical Synthesis:
Ethyl malonyl chloride is used in the syntheses of methanofullerodendrimers and 3-pyrrolin-2-ones, which are important building blocks in organic chemistry.
Used in Peptide Synthesis:
Ethyl malonyl chloride plays a vital role in the preparation of 3,5-disubstituted 1,2,4-oxadiazole derivatives, which are potential peptidomimetic building blocks, useful in the development of novel peptide-based drugs and therapeutic agents.
Used in Organic Chemistry Research:
Ethyl malonyl chloride is employed in the synthesis of 3-pyrrolin-2-ones via amidation with propargylamines and subsequent base-catalyzed 5-exo-dig cyclization, contributing to the advancement of organic chemistry research and the discovery of new chemical compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 36239-09-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,2,3 and 9 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 36239-09:
(7*3)+(6*6)+(5*2)+(4*3)+(3*9)+(2*0)+(1*9)=115
115 % 10 = 5
So 36239-09-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H6Cl2O2/c1-2-3(4(6)8)5(7)9/h3H,2H2,1H3
36239-09-5Relevant articles and documents
Single electron transfer induced elemental steps in the transformation of iodomalonic esters and related CH-acids under solid-liquid PTC conditions. Preparation of electrophilic cyclopropanes
Toke, Laszlo,Hell, Zoltan,Szabo, Gabor T.,Toth, Gabor,Bihari, Maria,Rockenbauer, Antal
, p. 5133 - 5146 (1993)
Single electron transfer induced elemental steps have been shown to occur during the transformation of iodomalonic esters and related CH-acids to cyclopropane derivatives under solid-liquid phase transfer catalytic conditions. The iodo derivatives are formed from iodine and CH-acids "in situ", in the same pot in which the transformations to cyclopropane derivatives take place. A number of electrophilic cyclopropanes with a wide range of substituents have been synthetised by this route.
TYK2 INHIBITORS AND USES THEREOF
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Paragraph 00843-00844, (2017/03/21)
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
DIHYDROPYRIDINONE MGAT2 INHIBITORS
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Paragraph 0430, (2016/10/08)
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.