2-Hydroxybicyclo[2.2.1]heptane-7-carboxylic acid

Base Information

• Chemical Name: 2-Hydroxybicyclo[2.2.1]heptane-7-carboxylic acid
• CAS No.: 60104-05-4
• Molecular Formula: C₈H₁₂O₃
• Molecular Weight: 156.181
• NSC Number: 167474
• DSSTox Substance ID: DTXSID60304819
• ChEMBL ID: CHEMBL1894839

Synonyms:MLS003106643;60104-05-4;2-hydroxybicyclo[2.2.1]heptane-7-carboxylic acid;NSC167474;Maybridge1_002533;Oprea1_217169;DivK1c_001285;CHEMBL1894839;HMS548L03;DTXSID60304819;BTBG 00114;NSC-167474;CDS1_000245;SMR001821535

Chemical Property of 2-Hydroxybicyclo[2.2.1]heptane-7-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.04E-05mmHg at 25°C
• Boiling Point: 332.5°Cat760mmHg
• Flash Point: 169.1°C
• Density: 1.364g/cm³
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 156.078644241
• Heavy Atom Count: 11
• Complexity: 190

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2C(CC1C2C(=O)O)O

Technology Process of 2-Hydroxybicyclo[2.2.1]heptane-7-carboxylic acid

There total 2 articles about 2-Hydroxybicyclo[2.2.1]heptane-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

5-norbornene-endo-2-carboxylic acid (934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7,120-74-1) → 4-hydroxybutyl-bicyclo[2.2.1]hept-5-ene-2-carboxylate-2-deoxy-3,4,6-tri-O-benzyl-α-D-galactopyranoside + Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide (136199-20-7) + 6-endo-hydroxy-5-exo-iodonorbornan-2-endo-ylcarboxylic acid γ-lactone (7732-50-5) + Norborn-2-exo-ol-syn-7-carboxylic-acid (60104-05-4,66808-01-3,68035-54-1,88588-60-7,88588-61-8,100164-30-5,100164-31-6,100164-32-7,101977-46-2,102629-66-3)

Guidance literature:

With iodine; sodium hydrogencarbonate; potassium iodide; In water;

DOI:10.1039/c3cc41645c

Reference yield: 21.0%

5-norbornene-endo-2-carboxylic acid (934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7,120-74-1) → 4-hydroxybutyl-bicyclo[2.2.1]hept-5-ene-2-carboxylate-2-deoxy-3,4,6-tri-O-benzyl-α-D-galactopyranoside + Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide (136199-20-7) + 6-endo-hydroxy-5-exo-iodonorbornan-2-endo-ylcarboxylic acid γ-lactone (7732-50-5) + Norborn-2-exo-ol-syn-7-carboxylic-acid (60104-05-4,66808-01-3,68035-54-1,88588-60-7,88588-61-8,100164-30-5,100164-31-6,100164-32-7,101977-46-2,102629-66-3) + C12H13NO4

Guidance literature:

With iodine; sodium hydrogencarbonate; potassium iodide; In water;

DOI:10.1039/c3cc41645c

Reference yield:

Norborn-2-exo-ol-syn-7-carboxylic-acid (60104-05-4,66808-01-3,68035-54-1,88588-60-7,88588-61-8,100164-30-5,100164-31-6,100164-32-7,101977-46-2,102629-66-3) → 2,3-Dideuterio-norbornyl-anti-7-carbinyl-p-brombenzolsulfonat (6139-51-1)

Guidance literature:

Multi-step reaction with 7 steps

1: CrO₃, Na₂SO₄, aq. H₂SO₄ / acetone

2: Br₂, HCl / CHCl₃

3: diethyl ether

4: LiAlH₄ / diethyl ether

5: Zn, AcOH / ethanol

6: dipotassium azodicarboxylate, AcOD / CH₃OD

With chromium(VI) oxide; hydrogenchloride; lithium aluminium tetrahydride; deuteroacetic acid; sulfuric acid; bromine; potassium diazodicarboxylate; acetic acid; sodium sulfate; zinc; In diethyl ether; ethanol; deuteromethanol; chloroform; acetone;

DOI:10.1021/ja01048a027

upstream raw materials:

5-norbornene-endo-2-carboxylic acid

Downstream raw materials:

2,3-Dideuterio-norbornyl-anti-7-carbinyl-p-brombenzolsulfonat

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 60104-05-4 2-hydroxybicyclo[2.2.1]heptane-7-carboxylic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send