2-phenyl-1H-indol-7-amine

Base Information

Chemical Name:2-phenyl-1H-indol-7-amine
CAS No.:500992-15-4
Molecular Formula:C14H12N2
Molecular Weight:208.263
Hs Code.:
DSSTox Substance ID:DTXSID601311949
Nikkaji Number:J1.813.234F

Synonyms:2-phenyl-1H-indol-7-amine;500992-15-4;SCHEMBL20496374;DTXSID601311949

Suppliers and Price of 2-phenyl-1H-indol-7-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-phenyl-1H-indol-7-amine

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:208.100048391
Heavy Atom Count:16
Complexity:235

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC3=C(N2)C(=CC=C3)N

Technology Process of 2-phenyl-1H-indol-7-amine

There total 3 articles about 2-phenyl-1H-indol-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 64890-06-8
7-nitro-2-phenylindole

: 500992-15-4
2-Phenyl-1H-indol-7-amine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃;
DOI:10.1016/S0040-4039(02)01851-8

Reference yield:

: 500992-09-6
N-[(6'-nitro-2'-phenylethynyl)phenyl]butyramide

: 500992-15-4
2-Phenyl-1H-indol-7-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / tBuOK / 1-methyl-pyrrolidin-2-one / 7 h / 60 - 70 °C

2: 86 percent / H₂ / Pd/C / ethanol / 20 °C

With potassium tert-butylate; hydrogen; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; ethanol;
DOI:10.1016/S0040-4039(02)01851-8

Reference yield:

: 536-74-3
phenylacetylene

: 500992-15-4
2-Phenyl-1H-indol-7-amine

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetra-(n-butyl)ammonium iodide; triethylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 7 h / 60 - 70 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; tetra-(n-butyl)ammonium iodide; triethylamine; In 1-methyl-pyrrolidin-2-one; ethanol; acetonitrile;
DOI:10.1002/cmdc.201000228