Formamide,N-[(1R,2R)-2-[4-(2-cyanoethoxy)phenyl]-2-hydroxy-1-(hydroxymethyl)ethyl]-

Base Information

Chemical Name:Formamide,N-[(1R,2R)-2-[4-(2-cyanoethoxy)phenyl]-2-hydroxy-1-(hydroxymethyl)ethyl]-
CAS No.:75347-13-6
Molecular Formula:C13H16 N2 O4
Molecular Weight:264.281
Hs Code.:

Synonyms:Formamide,N-[2-[4-(2-cyanoethoxy)phenyl]-2-hydroxy-1-(hydroxymethyl)ethyl]-,[R-(R*,R*)]-; (-)-Bursatellin; Bursatellin

Suppliers and Price of Formamide,N-[(1R,2R)-2-[4-(2-cyanoethoxy)phenyl]-2-hydroxy-1-(hydroxymethyl)ethyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Formamide,N-[(1R,2R)-2-[4-(2-cyanoethoxy)phenyl]-2-hydroxy-1-(hydroxymethyl)ethyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Formamide,N-[(1R,2R)-2-[4-(2-cyanoethoxy)phenyl]-2-hydroxy-1-(hydroxymethyl)ethyl]-

There total 23 articles about Formamide,N-[(1R,2R)-2-[4-(2-cyanoethoxy)phenyl]-2-hydroxy-1-(hydroxymethyl)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 129413-14-5
O,O-isopropylidene-(-)-bursatellin

: 75347-13-6
N-{(1R,2R)-1-[4-(2-cyanoethoxy)phenyl]-1,3-dihydroxypropan-2-yl}formamide

Guidance literature:: With methanol; camphor-10-sulfonic acid; for 24h; Ambient temperature;
DOI:10.1016/0040-4039(90)87038-2

Reference yield: 80.0%

: 1350705-85-9
N-((1R,2R)-1-(tert-butyldimethylsilyloxy)-1-(4-(2-cyanoethoxy)-phenyl)-3-hydroxypropan-2-yl)formamide

: 75347-13-6
N-{(1R,2R)-1-[4-(2-cyanoethoxy)phenyl]-1,3-dihydroxypropan-2-yl}formamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c1ob06320k

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 75347-13-6
N-{(1R,2R)-1-[4-(2-cyanoethoxy)phenyl]-1,3-dihydroxypropan-2-yl}formamide

Guidance literature:: Multi-step reaction with 10 steps

1: diethyl ether / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3: 90 percent / pyridine / Ambient temperature

4: 40 percent / aq. K₂S₂O₈, aq. CuSO₄ / acetonitrile / 1.67 h / Heating

5: 1.) aq. KOH / 1.) toluene, reflux, overnight, 2.) reflux, 9 h

6: 100 percent / H₂ / 10percent Pd/C / ethanol / 1 h

7: 67 percent / dl-camphorsulfonic acid / acetone / 3 h / Ambient temperature

8: 75 percent / K₂CO₃ / ethanol / 40 h / 90 °C

9: 73 percent / NaH₂PO₄ / dimethylsulfoxide

10: 72 percent / 80percent aq. acetic acid / 0.5 h / 100 °C

With pyridine; potassium hydroxide; sodium dihydrogenphosphate; dipotassium peroxodisulfate; lithium aluminium tetrahydride; camphor-10-sulfonic acid; hydrogen; potassium carbonate; copper(II) sulfate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dimethyl sulfoxide; acetone; acetonitrile;
DOI:10.1248/cpb.39.3170