METHYL-N-BOC-4-BENZYLOXY-L-PHENYL ALANINE

Base Information

• Chemical Name: METHYL-N-BOC-4-BENZYLOXY-L-PHENYL ALANINE
• CAS No.: 27513-44-6
• Molecular Formula: C22H27NO5
• Molecular Weight: 385.46
• Mol file: 27513-44-6.mol

Synonyms:(S)-methyl 3-(4-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanoate;N-(Boc)(O-benzyloxy)tyrosine methyl ester;(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester;methyl (2S)-2-{[(tert-butyloxy)carbonyl]amino}-3-{4-[(phenylmethyl)oxy]phenyl}propanoate;METHYL-N-BOC-4-BENZYLOXY-L-PHENYL ALANINE;(S)-methyl 3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanoate;N-Boc-L-tyrosine(OBn) methyl ester;

Chemical Property of METHYL-N-BOC-4-BENZYLOXY-L-PHENYL ALANINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• PSA: 73.86000
• LogP: 4.26530

Purity/Quality:

99% ^*data from raw suppliers

METHYL-N-BOC-4-BENZYLOXY-L-PHENYL-ALANINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL-N-BOC-4-BENZYLOXY-L-PHENYL ALANINE

There total 20 articles about METHYL-N-BOC-4-BENZYLOXY-L-PHENYL ALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester (4326-36-7) + benzyl bromide (100-39-0) → N-tert-butoxycarbonyl-O-benzyl-(S)-tyrosine methyl ester (27513-44-6)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; for 4h; Heating;

DOI:10.1016/j.tet.2005.08.073

Reference yield: 96.0%

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester (4326-36-7) + benzyl chloride (100-44-7) → N-tert-butoxycarbonyl-O-benzyl-(S)-tyrosine methyl ester (27513-44-6)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; for 10h; Reflux;

DOI:10.1016/j.bmc.2012.08.014

Reference yield: 95.0%

→ N-tert-butoxycarbonyl-O-benzyl-(S)-tyrosine methyl ester (27513-44-6)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 19h; Reflux;

upstream raw materials:

diazomethane

O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

diazomethyl-trimethyl-silane

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

Downstream raw materials:

O-benzyl-N-(tert-butoxycarbonyl)-L-tyrosinal

O-benzyl N-Boc-L-tyrosinol

N-ac-(O-benzyl)tyrosine

C₁₇H₁₉NO₅S