L-Phenylalanine, O-[(2,6-dichlorophenyl)methyl]-N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl glycylglycyl-, methyl ester

Base Information

• Chemical Name: L-Phenylalanine, O-[(2,6-dichlorophenyl)methyl]-N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl glycylglycyl-, methyl ester
• CAS No.: 501082-71-9
• Molecular Formula: C35H40Cl2N4O8
• Molecular Weight: 715.631
• Mol file: 501082-71-9.mol

Synonyms:

Chemical Property of L-Phenylalanine, O-[(2,6-dichlorophenyl)methyl]-N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl glycylglycyl-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Phenylalanine, O-[(2,6-dichlorophenyl)methyl]-N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl glycylglycyl-, methyl ester

There total 4 articles about L-Phenylalanine, O-[(2,6-dichlorophenyl)methyl]-N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl glycylglycyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (2S)-2-[[2-(t-butoxycarbonylamino)acetyl]amino]-3-phenylpropanoate (106624-70-8,41889-06-9) → Boc-Tyr(2,6-Cl2Bzl)-Gly-Gly-Phe-OMe (501082-71-9)

Guidance literature:

Multi-step reaction with 4 steps

1: HCl / ethyl acetate

2: DCC; HOBt

3: HCl / ethyl acetate

4: DCC; HOBt

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate;

DOI:10.1016/S0960-894X(02)00847-8

Reference yield:

(S)-methyl 12-benzyl-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate (63631-32-3) → Boc-Tyr(2,6-Cl2Bzl)-Gly-Gly-Phe-OMe (501082-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / ethyl acetate

2: DCC; HOBt

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate;

DOI:10.1016/S0960-894X(02)00847-8

Reference yield:

N--L-3-phenylalanine methyl ester hydrochloride (19240-24-5) → Boc-Tyr(2,6-Cl2Bzl)-Gly-Gly-Phe-OMe (501082-71-9)

Guidance literature:

Multi-step reaction with 3 steps

1: DCC; HOBt

2: HCl / ethyl acetate

3: DCC; HOBt

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate;

DOI:10.1016/S0960-894X(02)00847-8

upstream raw materials:

N-tert-butoxycarbonyl-O-2,6-dichlorobenzyl-L-tyrosine

N-glycyl>-L-3-phenylalanine methyl ester hydrochloride

methyl (2S)-2-[[2-(t-butoxycarbonylamino)acetyl]amino]-3-phenylpropanoate

(S)-methyl 12-benzyl-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

Downstream raw materials:

C₅₅H₆₆Cl₂N₆O₉

2-[2-(2-{2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

C₅₃H₆₀Cl₂N₆O₁₀

C₅₅H₆₆Cl₂N₆O₉

Refernces