63631-32-3

Basic information

• Product Name: L-Phenylalanine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]glycyl]-, methyl ester
• CAS NO: 63631-32-3
• Molecular Formula: C19H27N3O6
• Molecular Weight: 393.44
• Mol File: 63631-32-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]glycyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]glycyl]-, methyl ester(63631-32-3)
• EPA Substance Registry System: L-Phenylalanine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]glycyl]-, methyl ester(63631-32-3)

Safety Data

• Hazardous Substances Data: 63631-32-3(Hazardous Substances Data)

Upstream product

• 31972-52-8 Boc-Gly-Gly-OH 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 106624-70-8 methyl (2S)-2-[[2-(t-butoxycarbonylamino)acetyl]amino]-3-phenylpropanoate 
• 4530-20-5 BOC-glycine 
• 203053-87-6 (S)-methyl 2-(2-aminoacetamido)-3-phenylpropanoate trifluoroacetate salt 
• 63-91-2 L-phenylalanine 
• 3392-07-2 tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate 
• 19240-24-5 N--L-3-phenylalanine methyl ester hydrochloride 

Downstream Products

• 61131-29-1 N-glycyl>-L-3-phenylalanine methyl ester hydrochloride 
• 39621-73-3 N-t-butyloxycarbonylglycylglycyl-L-phenylalanine 
• 80164-29-0 N-t-butoxycarbonylglycylglycyl-L-phenylalanyl-L-leucine methyl ester 
• 35671-84-2 N-acetyl-glycyl-glycyl-L-phenylalanine methyl ester 
• 14281-57-3 N-acetyl-glycyl-L-phenylalanine methyl ester 
• 3618-96-0 (S)-N-acetylphenylalanine 
• 77511-32-1 5>-enkephalin 
• 61196-05-2 Boc-Tyr(Bzl)-Gly-Gly-Phe-OMe 
• 61131-30-4 Boc-L-Tyr(Bzl)-Gly-Gly-L-Phe-OH 
• 64963-27-5 N-tert-butyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine 
• 75244-08-5 4-nitrobenzyl ester of N-benzyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine 
• 81649-51-6 hydrochloride of 4-nitrobenzyl ester of glycyl-glycyl-L-phenylalanyl-L-leucine 
• 75244-06-3 4-nitrobenzyl ester of N-t-butyloxycarbonylglycylglycyl-L-phenylalanyl-L-leucine 
• 501082-99-1 C₅₇H₆₈Cl₂N₆O₁₀ 

Relevant articles and documents

Phenysilane and Silicon Tetraacetate: Versatile Promotors for Amide Synthesis

Phenylsilane was reevaluated as a useful coupling reagent for amide synthesis. At room temperature, a wide range of amides and peptides were obtained in good to excellent yields (up to 99 %). For the first time, Weinreb amides synthesis mediated by a hydrosilane were also documented. Comparative experiments with various acetoxysilanes suggested the involvement of a phenyl-triacyloxysilane. From this mechanistic study, silicon tetraacetate was shown as an efficient amine acylating agent.

Diphenylsilane as a coupling reagent for amide bond formation

A simple procedure for amide bond formation using diphenylsilane as a coupling reagent is described. This methodology enables the direct coupling of carboxylic acids with primary and secondary amines, releasing only hydrogen and a siloxane as by-products. Only one equivalent of each partner is needed, providing a more sustainable amidation method producing minimal wastes. This methodology was also extended to the synthesis of peptides and lactams by addition of Hünig's base (DIPEA) and 4-dimethylaminopyridine (DMAP).

Environmentally benign peptide synthesis using liquid-assisted ball-milling: Application to the synthesis of Leu-enkephalin

This paper describes an original methodology for peptide bond synthesis avoiding toxic solvents and reactants. Ball-milling stoichiometric amounts of Boc-protected α-amino acid N-carboxyanhydrides (Boc-AA-NCA) or Boc-protected α-amino acid N-hydroxysuccin