3-(6,7-Dihydro-2-Methyl-7-oxo-3-propyl-2H-pyrazolo[4,3-d]pyriMidin-5-yl)-4-ethoxy-benzenesulfonyl Chloride

Base Information

Chemical Name:3-(6,7-Dihydro-2-Methyl-7-oxo-3-propyl-2H-pyrazolo[4,3-d]pyriMidin-5-yl)-4-ethoxy-benzenesulfonyl Chloride
CAS No.:501120-42-9
Molecular Formula:C17H19ClN4O4S
Molecular Weight:410.87500
Hs Code.:
Mol file:501120-42-9.mol

Synonyms:Demethylpiperazinyl Iso Sildenafil Sulfonyl Chloride;

Suppliers and Price of 3-(6,7-Dihydro-2-Methyl-7-oxo-3-propyl-2H-pyrazolo[4,3-d]pyriMidin-5-yl)-4-ethoxy-benzenesulfonyl Chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DemethylpiperazinylIsoSildenafilSulfonylChloride
5mg
$ 195.00

Medical Isotopes, Inc.
DemethylpiperazinylIsoSildenafilSulfonylChloride
5 mg
$ 675.00

Total 2 raw suppliers

Chemical Property of 3-(6,7-Dihydro-2-Methyl-7-oxo-3-propyl-2H-pyrazolo[4,3-d]pyriMidin-5-yl)-4-ethoxy-benzenesulfonyl Chloride

Chemical Property:

Melting Point:207-210oC (dec.)
Boiling Point:621.4±65.0 °C(Predicted)
PKA:-0.17±0.20(Predicted)
PSA：115.32000
Density:1.48±0.1 g/cm3(Predicted)
LogP:3.68310
Storage Temp.:Refrigerator, under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

>=98% ^*data from raw suppliers

DemethylpiperazinylIsoSildenafilSulfonylChloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Iso Sildenafil (I900800) derivative. Intermediate in the preparation of Iso Sildenafil and Iso Viagra.

Technology Process of 3-(6,7-Dihydro-2-Methyl-7-oxo-3-propyl-2H-pyrazolo[4,3-d]pyriMidin-5-yl)-4-ethoxy-benzenesulfonyl Chloride

There total 8 articles about 3-(6,7-Dihydro-2-Methyl-7-oxo-3-propyl-2H-pyrazolo[4,3-d]pyriMidin-5-yl)-4-ethoxy-benzenesulfonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 501120-40-7
5-(2-ethoxyphenyl)-2-methyl-3-propyl-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-7-one

: 501120-42-9
5-(5-chlorosulfonyl-2-ethoxyphenyl)-2-methyl-3-propyl-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-7-one

Guidance literature:: With chlorosulfonic acid; at 65 - 70 ℃; for 1h;
DOI:10.1002/jhet.5570390532

Reference yield:

: 36983-31-0
ethyl 3-butyrylpyruvate

: 501120-42-9
5-(5-chlorosulfonyl-2-ethoxyphenyl)-2-methyl-3-propyl-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 0 - 5 °C

1.2: 36 percent / H₂SO₄ / 85 - 90 °C

2.1: 78 percent / H₂SO₄; HNO₃ / 90 - 95 °C

3.1: SOCl₂

3.2: 86 percent / NH₄OH; water / 3 h / 20 °C

4.1: HCl; SnCl₂; water / 20 °C

4.2: 90 percent / NaOH; water

5.1: 30 percent / polyphosphoric acid / Heating

6.1: 92 percent / chlorosulfonic acid / 1 h / 65 - 70 °C

With hydrogenchloride; chlorosulfonic acid; thionyl chloride; PPA; sulfuric acid; water; nitric acid; tin(ll) chloride; In methanol;
DOI:10.1002/jhet.5570390532

Reference yield:

: 134-11-2
2-ethoxybenzoic acid

: 501120-42-9
5-(5-chlorosulfonyl-2-ethoxyphenyl)-2-methyl-3-propyl-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / polyphosphoric acid / Heating

2: 92 percent / chlorosulfonic acid / 1 h / 65 - 70 °C

With chlorosulfonic acid; PPA;
DOI:10.1002/jhet.5570390532