134-11-2Relevant articles and documents
Copper-mediated direct alkoxylation of arenes using an N, O -bidentate directing system
Zhang, Lin-Bao,Hao, Xin-Qi,Zhang, Shou-Kun,Liu, Ke,Ren, Baozeng,Gong, Jun-Fang,Niu, Jun-Long,Song, Mao-Ping
, p. 10399 - 10409 (2014)
Highly effective CuCl-mediated C-H alkoxylation of arenes and heteroarenes has been developed by using a 2-aminopyridine 1-oxide moiety as an N,O-bidentate directing group. The reaction proceeds smoothly using a broad range of substrates to afford o-alkox
One-Pot Direct Oxidation of Primary Amines to Carboxylic Acids through Tandem ortho-Naphthoquinone-Catalyzed and TBHP-Promoted Oxidation Sequence
Kim, Hun Young,Oh, Kyungsoo,Si, Tengda
supporting information, p. 18150 - 18155 (2021/12/09)
Biomimetic oxidation of primary amines to carboxylic acids has been developed where the copper-containing amine oxidase (CuAO)-like o-NQ-catalyzed aerobic oxidation was combined with the aldehyde dehydrogenase (ALDH)-like TBHP-mediated imine oxidation protocol. Notably, the current tandem oxidation strategy provides a new mechanistic insight into the imine intermediate and the seemingly simple TBHP-mediated oxidation pathways of imines. The developed metal-free amine oxidation protocol allows the use of molecular oxygen and TBHP, safe forms of oxidant that may appeal to the industrial application.
O-ethoxy new synthetic process of formic acid
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Paragraph 0029; 0036-0040; 0041-0045; 0046-0050, (2019/04/04)
The invention belongs to the technical field of pharmaceutical intermediates, in particular to a O-ethoxy new synthetic process of formic acid. The alcohol into the reaction vessel, adding the solid KOH under stirring conditions, control the reaction temp
A 2-ethoxy carboxylic acid synthetic method of compound
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Paragraph 0020; 0022, (2017/03/24)
The invention discloses a synthesis method of a 2-ethoxybenzoic acid compound. The synthesis method comprises the following steps of orderly adding aromatic acylaminopyridine-1-oxide, cuprous chloride and an organic solvent into a reactor, stirring the mixture at a room temperature for 25-35min, adding potassium carbonate into the mixture after complex precipitates are produced, heating the reaction system to a temperature of 125-135 DEG C to cause a reaction lasting for 10-15h, after the reaction, carrying out extraction, drying, condensation and chromatographic separation to obtain an ethoxylated product, and carrying out alkaline hydrolysis and acidification to obtain the 2-ethoxybenzoic acid compound. The synthesis method has the advantages of easy acquisition of raw materials, cheap catalyst, mild reaction system, operation simpleness, high yield and substrate universality. The synthesis method has the yield of 87% and can realize guide base removal under mild conditions.