3,3'-oxybis(2-hydroxypropyl) diacetate

Base Information

• Chemical Name: 3,3'-oxybis(2-hydroxypropyl) diacetate
• CAS No.: 93820-00-9
• Molecular Formula: C10H18 O7
• Molecular Weight: 250.249
• Hs Code.: 2918199090
• Mol file: 93820-00-9.mol

Synonyms:3,3’-oxybis(2-hydroxypropyl) diacetate

Chemical Property of 3,3'-oxybis(2-hydroxypropyl) diacetate

Chemical Property:

• Boiling Point: 382.6°Cat760mmHg
• Flash Point: 143.3°C
• PSA: 102.29000
• Density: 1.234g/cm³
• LogP: -1.14900

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3'-oxybis(2-hydroxypropyl) diacetate

There total 2 articles about 3,3'-oxybis(2-hydroxypropyl) diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

vinyl acetate (108-05-4,9003-20-7) + diglycerol (627-82-7) → oxybis(2-hydroxypropan-3,1-diyl)diacetate (93820-00-9)

Guidance literature:

diglycerol; With immobilized Candida antarctica lipase; In tetrahydrofuran; for 0.166667h; Green chemistry; Enzymatic reaction;

vinyl acetate; In tetrahydrofuran; at 30 ℃; for 6h; regioselective reaction; Green chemistry;

DOI:10.3390/molecules21081038

Reference yield:

3,3'-oxybis(propane-1,2-diol) (36693-26-2) → oxybis(2-hydroxypropan-3,1-diyl)diacetate (93820-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dowex 50wx8 / methanol / 12 h / 50 °C

2: immobilized Candida antarctica lipase / tetrahydrofuran / 12 h / 30 °C / Enzymatic reaction

With immobilized Candida antarctica lipase; In tetrahydrofuran; methanol;

DOI:10.1039/d0ra07392j

Reference yield: 75.0%

oxybis(2-hydroxypropan-3,1-diyl)diacetate (93820-00-9) + 4-(prop-2-ynyloxy)benzoic acid (21926-55-6) → oxybis(1-acetoxypropane-3,2-diyl) bis(4-(prop-2-yn-1-yloxy)benzoate)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; for 15h; regioselective reaction; Green chemistry;

DOI:10.3390/molecules21081038

upstream raw materials:

vinyl acetate

diglycerol

3,3'-oxybis(propane-1,2-diol)

Refernces

• 1、 Aarti,Achazi, Katharina,Haag, Rainer,Mittal, Ayushi,Nie, Chuanxiong,Parmanand,Sharma, Sunil K.,Singh, Abhishek K.. "Oligo-glycerol based non-ionic amphiphilic nanocarriers for lipase mediated controlled drug release". . p. 37555 - 37563. Retrieved 2020/10/28.