Technology Process of 2-Cyclohexen-1-one, 5,6-dimethyl-, (5R)-
There total 3 articles about 2-Cyclohexen-1-one, 5,6-dimethyl-, (5R)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2RS,3R)-2,3-dimethylcyclohexanone;
With
chloro-trimethyl-silane; bromine; lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 4h;
Inert atmosphere;
With
lithium carbonate; lithium bromide;
In
N,N-dimethyl-formamide;
at 100 ℃;
for 4h;
Inert atmosphere;
DOI:10.1002/ejoc.201600538
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 70 percent / LDA; LiCl
2.1: 75 percent / KOH / Heating
3.1: diisopropyl amine; n-butyllithium; triethylamine / chlorotrimethylsilane / tetrahydrofuran; petroleum ether / -78 - 0 °C
3.2: bromine / tetrahydrofuran; petroleum ether / 2 h / -78 °C
4.1: 5.0 g / lithium carbonate; lithium bromide / dimethylformamide / 4 h / 100 - 105 °C
With
potassium hydroxide; n-butyllithium; lithium carbonate; triethylamine; diisopropylamine; lithium chloride; lithium bromide; lithium diisopropyl amide;
chloro-trimethyl-silane;
In
tetrahydrofuran; N,N-dimethyl-formamide; Petroleum ether;
DOI:10.1021/ja0296531
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 75 percent / KOH / Heating
2.1: diisopropyl amine; n-butyllithium; triethylamine / chlorotrimethylsilane / tetrahydrofuran; petroleum ether / -78 - 0 °C
2.2: bromine / tetrahydrofuran; petroleum ether / 2 h / -78 °C
3.1: 5.0 g / lithium carbonate; lithium bromide / dimethylformamide / 4 h / 100 - 105 °C
With
potassium hydroxide; n-butyllithium; lithium carbonate; triethylamine; diisopropylamine; lithium bromide;
chloro-trimethyl-silane;
In
tetrahydrofuran; N,N-dimethyl-formamide; Petroleum ether;
DOI:10.1021/ja0296531
