Technology Process of Cyclohexanone, 6-bromo-2,3-dimethyl-, (3R)-
There total 3 articles about Cyclohexanone, 6-bromo-2,3-dimethyl-, (3R)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2RS,3R)-2,3-dimethylcyclohexanone;
With
n-butyllithium; triethylamine; diisopropylamine;
chloro-trimethyl-silane;
In
tetrahydrofuran; Petroleum ether;
at -78 - 0 ℃;
With
bromine;
In
tetrahydrofuran; Petroleum ether;
at -78 ℃;
for 2h;
Further stages.;
DOI:10.1021/ja0296531
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 70 percent / LDA; LiCl
2.1: 75 percent / KOH / Heating
3.1: diisopropyl amine; n-butyllithium; triethylamine / chlorotrimethylsilane / tetrahydrofuran; petroleum ether / -78 - 0 °C
3.2: bromine / tetrahydrofuran; petroleum ether / 2 h / -78 °C
With
potassium hydroxide; n-butyllithium; triethylamine; diisopropylamine; lithium chloride; lithium diisopropyl amide;
chloro-trimethyl-silane;
In
tetrahydrofuran; Petroleum ether;
DOI:10.1021/ja0296531
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 75 percent / KOH / Heating
2.1: diisopropyl amine; n-butyllithium; triethylamine / chlorotrimethylsilane / tetrahydrofuran; petroleum ether / -78 - 0 °C
2.2: bromine / tetrahydrofuran; petroleum ether / 2 h / -78 °C
With
potassium hydroxide; n-butyllithium; triethylamine; diisopropylamine;
chloro-trimethyl-silane;
In
tetrahydrofuran; Petroleum ether;
DOI:10.1021/ja0296531
