3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl methyl sulfide

Base Information

• Chemical Name: 3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl methyl sulfide
• CAS No.: 501370-44-1
• Molecular Formula: C12H10ClN5S
• Molecular Weight: 291.75900
• Mol file: 501370-44-1.mol

Synonyms:3-(2-Chloro-benzyl)-7-methylsulfanyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine;

Chemical Property of 3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl methyl sulfide

Chemical Property:

• Melting Point: 137 - 140 °C (methanol)
• PSA: 81.79000
• LogP: 2.64490

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl methyl sulfide

There total 2 articles about 3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl methyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-(2-chlorobenzyl)-7-mercapto-1,2,3-triazolo[4,5-d] pyrimidine (501370-42-9) + methyl iodide (74-88-4) → 3-(2-chlorobenzyl)-7-methylthio-1,2,3-triazolo[4,5-d] pyrimidine (501370-44-1)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 0.333333h;

DOI:10.1002/jhet.5570390505

Reference yield:

3-(2-chlorobenzyl)-7-chloro-1,2,3-triazolo[4,5-d]pyrimidine (201541-70-0) → 3-(2-chlorobenzyl)-7-methylthio-1,2,3-triazolo[4,5-d] pyrimidine (501370-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / methanol / 0.42 h / Heating

2: 68 percent / aq. sodium hydroxide / 0.33 h / 20 °C

With sodium hydroxide; In methanol;

DOI:10.1002/jhet.5570390505

Reference yield: 87.0%

3-(2-chlorobenzyl)-7-methylthio-1,2,3-triazolo[4,5-d] pyrimidine (501370-44-1) → 3-(2-chlorobenzyl)-7-hydrazino-1,2,3-triazolo[4,5-d]pyrimidine

Guidance literature:

With hydrazine hydrate; In methanol; at 20 ℃; for 0.666667h;

DOI:10.1002/jhet.5570390505

upstream raw materials:

3-(2-chlorobenzyl)-7-mercapto-1,2,3-triazolo[4,5-d] pyrimidine

methyl iodide

3-(2-chlorobenzyl)-7-chloro-1,2,3-triazolo[4,5-d]pyrimidine

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