1H-Pyrazole-3-carboxylic acid, 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-

Base Information

Chemical Name:1H-Pyrazole-3-carboxylic acid, 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-
CAS No.:501423-63-8
Molecular Formula:C17H11BrCl2N2O2
Molecular Weight:426.097
Hs Code.:

Synonyms:5-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid;5-(4-Bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid;1-(2,4-dichlorophenyl)-5-(4-bromophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid;

Suppliers and Price of 1H-Pyrazole-3-carboxylic acid, 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrazole-3-carboxylic acid, 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-

Chemical Property:

Melting Point:182-183 °C
Boiling Point:567.2±50.0 °C(Predicted)
PSA：55.12000
Density:1.63±0.1 g/cm3(Predicted)
LogP:5.61520

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-3-carboxylic acid, 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-

There total 5 articles about 1H-Pyrazole-3-carboxylic acid, 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 183232-62-4
5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 501423-63-8
5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: With potassium hydroxide; In methanol; water; for 5h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmcl.2019.126644

Reference yield: 85.0%

: 501423-63-8
5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

Guidance literature:

Reference yield:

: 10342-83-3
4'-Bromopropiophenone

: 501423-63-8
5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LiHMDS / 1.) hexane, diethyl ether, -78 deg C, 45 min, 2.) hexane, diethyl ether, RT, 16 h

2: 2.) AcOH / 1.) EtOH, RT, 20 h, 2.) reflux, 24 h

3: KOH / methanol / 3 h / Heating

With potassium hydroxide; acetic acid; lithium hexamethyldisilazane; In methanol;
DOI:10.1021/jm980363y