1H-Pyrazole-3-carboxamide, 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-

Base Information

Chemical Name:1H-Pyrazole-3-carboxamide, 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-
CAS No.:183232-63-5
Molecular Formula:C22H21BrCl2N4O
Molecular Weight:508.245
Hs Code.:
Mol file:183232-63-5.mol

Synonyms:5-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide;N-piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide;N-(piperidin-1-yl)-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide;5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide;

Suppliers and Price of 1H-Pyrazole-3-carboxamide, 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrazole-3-carboxamide, 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-

Chemical Property:

PSA：50.16000
LogP:6.37650

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-3-carboxamide, 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-

There total 4 articles about 1H-Pyrazole-3-carboxamide, 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 2213-43-6
1-Aminopiperidine

: 183232-64-6
5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic chloride

: 183232-63-5
1-(2,4-dichlorophenyl)-5-(4-bromophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1002/(SICI)1099-1344(199610)38:10<875::AID-JLCR908>3.0.CO;2-G DOI:10.1021/jm980363y

Reference yield:

: 183232-62-4
5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 183232-63-5
1-(2,4-dichlorophenyl)-5-(4-bromophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: KOH / methanol / 3 h / Heating

2: SOCl₂ / toluene / 3 h / Heating

3: 96 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With potassium hydroxide; thionyl chloride; triethylamine; In methanol; dichloromethane; toluene;
DOI:10.1021/jm980363y

Reference yield:

: 10342-83-3
4'-Bromopropiophenone

: 183232-63-5
1-(2,4-dichlorophenyl)-5-(4-bromophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LiHMDS / 1.) hexane, diethyl ether, -78 deg C, 45 min, 2.) hexane, diethyl ether, RT, 16 h

2: 2.) AcOH / 1.) EtOH, RT, 20 h, 2.) reflux, 24 h

3: KOH / methanol / 3 h / Heating

4: SOCl₂ / toluene / 3 h / Heating

5: 96 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With potassium hydroxide; thionyl chloride; acetic acid; triethylamine; lithium hexamethyldisilazane; In methanol; dichloromethane; toluene;
DOI:10.1021/jm980363y