2H-Pyran-3-ol, 4-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethylidene]-2-[1,1-dimethyl-2-( phenylsulfonyl)ethyl]tetrahydro-2-methoxy-6-[[(4R,5R)-2,2,5-trimethyl-1, 3-dioxolan-4-yl]methyl]-, (2S,3S,4E,6S)-

Base Information

Chemical Name:2H-Pyran-3-ol, 4-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethylidene]-2-[1,1-dimethyl-2-( phenylsulfonyl)ethyl]tetrahydro-2-methoxy-6-[[(4R,5R)-2,2,5-trimethyl-1, 3-dioxolan-4-yl]methyl]-, (2S,3S,4E,6S)-
CAS No.:501677-46-9
Molecular Formula:C41H56O8SSi
Molecular Weight:737.042
Hs Code.:

2H-Pyran-3-ol,
4-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethylidene]-2-[1,1-dimethyl-2-(
phenylsulfonyl)ethyl]tetrahydro-2-methoxy-6-[[(4R,5R)-2,2,5-trimethyl-1,
3-dioxolan-4-yl]methyl]-, (2S,3S,4E,6S)-

Synonyms:

Suppliers and Price of 2H-Pyran-3-ol, 4-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethylidene]-2-[1,1-dimethyl-2-( phenylsulfonyl)ethyl]tetrahydro-2-methoxy-6-[[(4R,5R)-2,2,5-trimethyl-1, 3-dioxolan-4-yl]methyl]-, (2S,3S,4E,6S)-

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Chemical Property of 2H-Pyran-3-ol, 4-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethylidene]-2-[1,1-dimethyl-2-( phenylsulfonyl)ethyl]tetrahydro-2-methoxy-6-[[(4R,5R)-2,2,5-trimethyl-1, 3-dioxolan-4-yl]methyl]-, (2S,3S,4E,6S)-

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Technology Process of 2H-Pyran-3-ol, 4-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethylidene]-2-[1,1-dimethyl-2-( phenylsulfonyl)ethyl]tetrahydro-2-methoxy-6-[[(4R,5R)-2,2,5-trimethyl-1, 3-dioxolan-4-yl]methyl]-, (2S,3S,4E,6S)-

There total 6 articles about 2H-Pyran-3-ol, 4-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethylidene]-2-[1,1-dimethyl-2-( phenylsulfonyl)ethyl]tetrahydro-2-methoxy-6-[[(4R,5R)-2,2,5-trimethyl-1, 3-dioxolan-4-yl]methyl]-, (2S,3S,4E,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501677-45-8
(2S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-dihydro-pyran-3-one

: 501677-46-9
(2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-tetrahydro-pyran-3-ol

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In methanol; at -78 - 20 ℃;
DOI:10.1021/ol027393m

Reference yield:

: 380579-24-8
6-(2-benzenesulfonyl-1,1-dimethyl-ethyl)-2-[2,3-bis-(tert-butyl-dimethyl-silanyloxy)-butyl]-3,4-dihydro-2H-pyran

: 501677-46-9
(2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-tetrahydro-pyran-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / n-Bu₄NF / tetrahydrofuran / 12 h / 20 °C

2.1: 97 percent / PPTS / acetone / 0.25 h / 40 °C

3.1: DMDO; Me₂C(OMe)2 / acetone; methanol / 0.25 h / 0 °C

3.2: PPTS; Me₂C(OMe)2 / acetone / 0.17 h / 20 °C

4.1: PDC / dimethylformamide / 20 h / 20 °C

5.1: n-BuLi / hexane; tetrahydrofuran / 0.23 h / -78 °C

5.2: 75 percent / hexane; tetrahydrofuran / 0.42 h / -78 - 0 °C

6.1: NaBH₄; CeCl₃*7H₂O / methanol / -78 - 20 °C

With sodium tetrahydroborate; dipyridinium dichromate; n-butyllithium; cerium(III) chloride; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; 2,2-dimethoxy-propane; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetone; 6.1: Luche reduction;
DOI:10.1021/ol027393m

Reference yield:

: 501677-41-4
(2R,3R)-1-[(S)-6-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2H-pyran-2-yl]-butane-2,3-diol

: 501677-46-9
(2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-tetrahydro-pyran-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 97 percent / PPTS / acetone / 0.25 h / 40 °C

2.1: DMDO; Me₂C(OMe)2 / acetone; methanol / 0.25 h / 0 °C

2.2: PPTS; Me₂C(OMe)2 / acetone / 0.17 h / 20 °C

3.1: PDC / dimethylformamide / 20 h / 20 °C

4.1: n-BuLi / hexane; tetrahydrofuran / 0.23 h / -78 °C

4.2: 75 percent / hexane; tetrahydrofuran / 0.42 h / -78 - 0 °C

5.1: NaBH₄; CeCl₃*7H₂O / methanol / -78 - 20 °C

With sodium tetrahydroborate; dipyridinium dichromate; n-butyllithium; cerium(III) chloride; pyridinium p-toluenesulfonate; 2,2-dimethoxy-propane; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetone; 5.1: Luche reduction;
DOI:10.1021/ol027393m