(S)-6-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-2-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-3,4-dihydro-2H-pyran

Base Information

• Chemical Name: (S)-6-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-2-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-3,4-dihydro-2H-pyran
• CAS No.: 501677-42-5
• Molecular Formula: C₂₂H₃₂O₅S
• Molecular Weight: 408.559
• Mol file: 501677-42-5.mol

Synonyms:(S)-6-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-2-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-3,4-dihydro-2H-pyran

Chemical Property of (S)-6-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-2-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-3,4-dihydro-2H-pyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-2-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-3,4-dihydro-2H-pyran

There total 10 articles about (S)-6-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-2-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-3,4-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,2-dimethoxy-propane (77-76-9) + (2R,3R)-1-[(S)-6-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2H-pyran-2-yl]-butane-2,3-diol (501677-41-4) → (S)-6-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-2-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-3,4-dihydro-2H-pyran (501677-42-5)

Guidance literature:

With pyridinium p-toluenesulfonate; In acetone; at 40 ℃; for 0.25h;

DOI:10.1021/ol027393m

Reference yield: 84.0%

2,2-dimethoxy-propane (77-76-9) + 1-Benzenesulfonyl-6-[(4S,6R)-6-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2,2-dimethyl-hexan-3-one (1053256-74-8) → (S)-6-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-2-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-3,4-dihydro-2H-pyran (501677-42-5)

Guidance literature:

With camphor-10-sulfonic acid; In toluene; at 20 ℃; for 5h;

DOI:10.1021/jo0495081

Reference yield: 75.0%

(E)-1-Benzenesulfonyl-6-[(4S,6R)-6-((R)-1-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2,2-dimethyl-hex-4-en-3-one (718620-98-5) → (S)-6-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-2-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-3,4-dihydro-2H-pyran (501677-42-5)

Guidance literature:

(E)-1-Benzenesulfonyl-6-[(4S,6R)-6-((R)-1-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2,2-dimethyl-hex-4-en-3-one; With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃;

With camphor-10-sulfonic acid; 2,2-dimethoxy-propane; In toluene; at 20 ℃; for 5h;

DOI:10.1021/jo0495081

upstream raw materials:

2,2-dimethoxy-propane

(2R,3R)-1-[(S)-6-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2H-pyran-2-yl]-butane-2,3-diol

1-Benzenesulfonyl-6-[(4S,6R)-6-((R)-1-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2,2-dimethyl-hexan-3-one

(E)-1-Benzenesulfonyl-6-[(4S,6R)-6-((R)-1-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-2,2-dimethyl-hex-4-en-3-one

Downstream raw materials:

(2S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-2-methoxy-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-tetrahydro-pyran-3-ol

(2S,3S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-tetrahydro-pyran-3-ol

(2S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-4-[2-(tert-butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-methoxy-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-dihydro-pyran-3-one

(2S,6S)-2-(2-Benzenesulfonyl-1,1-dimethyl-ethyl)-2-methoxy-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-ylmethyl)-dihydro-pyran-3-one