1-Piperidinecarboxylic acid, 4-[2-[[[[[[4-[[[(1S)-1-methyl-2-oxo-2-(phenylmethoxy)ethyl]amino]carbonyl ]phenyl]methyl]amino]carbonyl]oxy]methoxy]-2-oxoethoxy]-, phenylmethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[2-[[[[[[4-[[[(1S)-1-methyl-2-oxo-2-(phenylmethoxy)ethyl]amino]carbonyl ]phenyl]methyl]amino]carbonyl]oxy]methoxy]-2-oxoethoxy]-, phenylmethyl ester
CAS No.:502158-13-6
Molecular Formula:C35H39N3O10
Molecular Weight:661.709
Hs Code.:

1-Piperidinecarboxylic acid,
4-[2-[[[[[[4-[[[(1S)-1-methyl-2-oxo-2-(phenylmethoxy)ethyl]amino]carbonyl
]phenyl]methyl]amino]carbonyl]oxy]methoxy]-2-oxoethoxy]-, phenylmethyl
ester

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 4-[2-[[[[[[4-[[[(1S)-1-methyl-2-oxo-2-(phenylmethoxy)ethyl]amino]carbonyl ]phenyl]methyl]amino]carbonyl]oxy]methoxy]-2-oxoethoxy]-, phenylmethyl ester

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Technology Process of 1-Piperidinecarboxylic acid, 4-[2-[[[[[[4-[[[(1S)-1-methyl-2-oxo-2-(phenylmethoxy)ethyl]amino]carbonyl ]phenyl]methyl]amino]carbonyl]oxy]methoxy]-2-oxoethoxy]-, phenylmethyl ester

There total 6 articles about 1-Piperidinecarboxylic acid, 4-[2-[[[[[[4-[[[(1S)-1-methyl-2-oxo-2-(phenylmethoxy)ethyl]amino]carbonyl ]phenyl]methyl]amino]carbonyl]oxy]methoxy]-2-oxoethoxy]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 502158-15-8
(S)-2-[4-(Chloromethoxycarbonylamino-methyl)-benzoylamino]-propionic acid benzyl ester

: 2-[(1-benzyloxycarbonyl-4-piperidinyl)oxy]acetic acid cesium salt

: 502158-13-6
4-[4-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-benzylcarbamoyloxymethoxycarbonylmethoxy]-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0045-2068(02)00013-5

Reference yield:

: 101623-71-6
iodomethyl(4-nitrophenyl)carbonate

: 2-[(1-benzyloxycarbonyl-4-piperidinyl)oxy]acetic acid cesium salt

: N-[4-(aminomethyl)benzoyl]alanine benzyl ester trifluoroacetate

: 4-{[4-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-benzylcarbamoyl]-methoxy}-piperidine-1-carboxylic acid benzyl ester

: 502158-13-6
4-[4-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-benzylcarbamoyloxymethoxycarbonylmethoxy]-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: iodomethyl(4-nitrophenyl)carbonate; 2-[(1-benzyloxycarbonyl-4-piperidinyl)oxy]acetic acid cesium salt; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 31h;

N-[4-(aminomethyl)benzoyl]alanine benzyl ester trifluoroacetate; With 4-methyl-morpholine; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1016/S0045-2068(02)00013-5

Reference yield:

: 56-91-7
p-aminomethylbenzoic acid

: 502158-13-6
4-[4-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-benzylcarbamoyloxymethoxycarbonylmethoxy]-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / NaOH / dioxane; H₂O / 0 - 20 °C / pH 9.0

2.1: 99 percent / HOBT; EDC; N-methylmorpholine / CH₂Cl₂ / 28 h / 0 - 25 °C

3.1: 100 percent / CH₂Cl₂ / 0 - 20 °C

4.1: dimethylformamide / 31 h / 0 - 25 °C

4.2: 1.035 g / N-methylmorpholine; HOBT / dimethylformamide / 3 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0045-2068(02)00013-5