Benzoic acid, 4-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4-ethyl-6-methyl-1H-pyrrolo[2, 3-d]pyrimidin-5-yl]ethyl]-, methyl ester

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Chemical Name:Benzoic acid, 4-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4-ethyl-6-methyl-1H-pyrrolo[2, 3-d]pyrimidin-5-yl]ethyl]-, methyl ester
CAS No.:502160-50-1
Molecular Formula:C24H30N4O3
Molecular Weight:422.527
Hs Code.:

Synonyms:

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Chemical Property of Benzoic acid, 4-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4-ethyl-6-methyl-1H-pyrrolo[2, 3-d]pyrimidin-5-yl]ethyl]-, methyl ester

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Technology Process of Benzoic acid, 4-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4-ethyl-6-methyl-1H-pyrrolo[2, 3-d]pyrimidin-5-yl]ethyl]-, methyl ester

There total 6 articles about Benzoic acid, 4-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4-ethyl-6-methyl-1H-pyrrolo[2, 3-d]pyrimidin-5-yl]ethyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 502160-49-8
methyl 4-[2-(2-pivaloylamino-4-vinyl-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

: 502160-50-1
methyl 4-[2-(2-pivaloylamino-4-ethyl-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

Guidance literature:: With hydrogen; 5percent Pd/C; In tetrahydrofuran; dichloromethane; for 18h; under 2585.81 Torr;
DOI:10.1021/jm0203534

Reference yield:

: 111957-98-3,625-31-0
Pent-4-en-2-ol

: 502160-50-1
methyl 4-[2-(2-pivaloylamino-4-ethyl-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / tetra-n-butylammonium chloride; lithium acetate; lithium chloride / palladium acetate

2: 85 percent / 2-methoxy-ethanol / Heating

3: 47 percent / diphenyl ether / 5 h / Heating

4: 96 percent / pyridine / 3.5 h / Heating

5: 90 percent / phosphorus oxychloride / 2.5 h / 120 °C

6: 67 percent / Pd(PPh₃)2Cl₂ / toluene / 4 h / Heating

7: 92 percent / H₂ / 5percent Pd/C / tetrahydrofuran; CH₂Cl₂ / 18 h / 2585.81 Torr

With pyridine; bis-triphenylphosphine-palladium(II) chloride; lithium acetate; tetrabutyl-ammonium chloride; hydrogen; lithium chloride; trichlorophosphate; palladium diacetate; In tetrahydrofuran; diphenylether; dichloromethane; 2-methoxy-ethanol; toluene; 6: Stille coupling;
DOI:10.1021/jm0203534

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 502160-50-1
methyl 4-[2-(2-pivaloylamino-4-ethyl-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / tetra-n-butylammonium chloride; lithium acetate; lithium chloride / palladium acetate

2: 85 percent / 2-methoxy-ethanol / Heating

3: 47 percent / diphenyl ether / 5 h / Heating

4: 96 percent / pyridine / 3.5 h / Heating

5: 90 percent / phosphorus oxychloride / 2.5 h / 120 °C

6: 67 percent / Pd(PPh₃)2Cl₂ / toluene / 4 h / Heating

7: 92 percent / H₂ / 5percent Pd/C / tetrahydrofuran; CH₂Cl₂ / 18 h / 2585.81 Torr

With pyridine; bis-triphenylphosphine-palladium(II) chloride; lithium acetate; tetrabutyl-ammonium chloride; hydrogen; lithium chloride; trichlorophosphate; palladium diacetate; In tetrahydrofuran; diphenylether; dichloromethane; 2-methoxy-ethanol; toluene; 6: Stille coupling;
DOI:10.1021/jm0203534