methyl 4-[2-(2-pivaloylamino-4-vinyl-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

Base Information

Chemical Name:methyl 4-[2-(2-pivaloylamino-4-vinyl-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate
CAS No.:502160-49-8
Molecular Formula:C₂₄H₂₈N₄O₃
Molecular Weight:420.511
Hs Code.:

Synonyms:methyl 4-[2-(2-pivaloylamino-4-vinyl-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

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Chemical Property of methyl 4-[2-(2-pivaloylamino-4-vinyl-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

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Technology Process of methyl 4-[2-(2-pivaloylamino-4-vinyl-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

There total 7 articles about methyl 4-[2-(2-pivaloylamino-4-vinyl-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 7486-35-3
tri-n-butyl(vinyl)tin

: 502160-48-7
methyl 4-[2-(2-pivaloylamino-4-chloro-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

: 502160-49-8
methyl 4-[2-(2-pivaloylamino-4-vinyl-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; In toluene; for 4h; Heating;
DOI:10.1021/jm0203534

Reference yield:

: 111957-98-3,625-31-0
Pent-4-en-2-ol

: 502160-49-8
methyl 4-[2-(2-pivaloylamino-4-vinyl-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / tetra-n-butylammonium chloride; lithium acetate; lithium chloride / palladium acetate

2: 85 percent / 2-methoxy-ethanol / Heating

3: 47 percent / diphenyl ether / 5 h / Heating

4: 96 percent / pyridine / 3.5 h / Heating

5: 90 percent / phosphorus oxychloride / 2.5 h / 120 °C

6: 67 percent / Pd(PPh₃)2Cl₂ / toluene / 4 h / Heating

With pyridine; bis-triphenylphosphine-palladium(II) chloride; lithium acetate; tetrabutyl-ammonium chloride; lithium chloride; trichlorophosphate; palladium diacetate; In diphenylether; 2-methoxy-ethanol; toluene; 6: Stille coupling;
DOI:10.1021/jm0203534

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 502160-49-8
methyl 4-[2-(2-pivaloylamino-4-vinyl-6-methylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / tetra-n-butylammonium chloride; lithium acetate; lithium chloride / palladium acetate

2: 85 percent / 2-methoxy-ethanol / Heating

3: 47 percent / diphenyl ether / 5 h / Heating

4: 96 percent / pyridine / 3.5 h / Heating

5: 90 percent / phosphorus oxychloride / 2.5 h / 120 °C

6: 67 percent / Pd(PPh₃)2Cl₂ / toluene / 4 h / Heating

With pyridine; bis-triphenylphosphine-palladium(II) chloride; lithium acetate; tetrabutyl-ammonium chloride; lithium chloride; trichlorophosphate; palladium diacetate; In diphenylether; 2-methoxy-ethanol; toluene; 6: Stille coupling;
DOI:10.1021/jm0203534