Chemical Property of (5Z,8Z,11Z,14Z)-16-hydroxyicosa-5,8,11,14-tetraenoic acid
Chemical Property:
- Vapor Pressure:4.1E-11mmHg at 25°C
- Boiling Point:477.3°Cat760mmHg
- Flash Point:256.6°C
- PSA：57.53000
- Density:0.984g/cm3
- LogP:5.18750
- XLogP3:4.8
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:14
- Exact Mass:320.23514488
- Heavy Atom Count:23
- Complexity:392
- Purity/Quality:
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≥98% *data from raw suppliers
(±)16-HETE ≥98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCCCC(C=CCC=CCC=CCC=CCCCC(=O)O)O
- Isomeric SMILES:CCCCC(/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O)O
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Description
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.
