Carbamic acid, [(1S)-1-[(acetyloxy)methyl]-1-[[(3,4-dimethoxyphenyl)methoxy]methyl]-2- propynyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [(1S)-1-[(acetyloxy)methyl]-1-[[(3,4-dimethoxyphenyl)methoxy]methyl]-2- propynyl]-, 1,1-dimethylethyl ester
• CAS No.: 502183-36-0
• Molecular Formula: C21H29NO7
• Molecular Weight: 407.464
• Mol file: 502183-36-0.mol

Synonyms:

Chemical Property of Carbamic acid, [(1S)-1-[(acetyloxy)methyl]-1-[[(3,4-dimethoxyphenyl)methoxy]methyl]-2- propynyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [(1S)-1-[(acetyloxy)methyl]-1-[[(3,4-dimethoxyphenyl)methoxy]methyl]-2- propynyl]-, 1,1-dimethylethyl ester

There total 4 articles about Carbamic acid, [(1S)-1-[(acetyloxy)methyl]-1-[[(3,4-dimethoxyphenyl)methoxy]methyl]-2- propynyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,4-dimethoxybenzyloxy)-3-nitropyridine (464896-41-1) + (S)-(1-acetyloxymethyl-1-hydroxymethylprop-2-ynyl)carbamic acid tert-butyl ester (502183-35-9) → acetic acid 2-tert-butoxycarbonylamino-2-(3,4-dimethoxy-benzyloxymethyl)-but-3-ynyl ester (502183-36-0)

Guidance literature:

With camphor-10-sulfonic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/jo020532t

Reference yield:

(3,4-dimethoxyphenyl)methanol (93-03-8) → acetic acid 2-tert-butoxycarbonylamino-2-(3,4-dimethoxy-benzyloxymethyl)-but-3-ynyl ester (502183-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / KOH; K₂CO₃; tris(3,6-dioxaheptylamine) / toluene / 3 h

2: camphorsulfonic acid / CH₂Cl₂ / 20 °C

With potassium hydroxide; camphor-10-sulfonic acid; Tris(3,6-dioxaheptyl)amine; potassium carbonate; In dichloromethane; toluene;

DOI:10.1021/jo020532t

Reference yield:

(1,1-bis-hydroxymethyl-prop-2-ynyl)-carbamic acid tert-butyl ester (364631-69-6) → acetic acid 2-tert-butoxycarbonylamino-2-(3,4-dimethoxy-benzyloxymethyl)-but-3-ynyl ester (502183-36-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / DMAP / pyridine / 12 h / 20 °C

2: pig liver esterase; phosphate buffer / acetonitrile / 3 h / 20 °C / pH 6.5

3: camphorsulfonic acid / CH₂Cl₂ / 20 °C

With dmap; phosphate buffer; pig liver esterase; camphor-10-sulfonic acid; In pyridine; dichloromethane; acetonitrile;

DOI:10.1021/jo020532t

upstream raw materials:

2-(3,4-dimethoxybenzyloxy)-3-nitropyridine

(S)-(1-acetyloxymethyl-1-hydroxymethylprop-2-ynyl)carbamic acid tert-butyl ester

(3,4-dimethoxyphenyl)methanol

(1,1-bis-hydroxymethyl-prop-2-ynyl)-carbamic acid tert-butyl ester

Downstream raw materials:

(S)-[1-(tert-butyldimethylsilanyloxymethyl)-1-(3,4-dimethoxybenzyloxymethyl)prop-2-ynyl]carbamic acid tert-butyl ester