Carbamic acid, [(1S)-1-[[(3,4-dimethoxyphenyl)methoxy]methyl]-1-[[[(1,1-dimethylethyl)di methylsilyl]oxy]methyl]-2-propynyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S)-1-[[(3,4-dimethoxyphenyl)methoxy]methyl]-1-[[[(1,1-dimethylethyl)di methylsilyl]oxy]methyl]-2-propynyl]-, 1,1-dimethylethyl ester
CAS No.:502183-37-1
Molecular Formula:C25H41NO6Si
Molecular Weight:479.689
Hs Code.:

Carbamic acid,
[(1S)-1-[[(3,4-dimethoxyphenyl)methoxy]methyl]-1-[[[(1,1-dimethylethyl)di
methylsilyl]oxy]methyl]-2-propynyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [(1S)-1-[[(3,4-dimethoxyphenyl)methoxy]methyl]-1-[[[(1,1-dimethylethyl)di methylsilyl]oxy]methyl]-2-propynyl]-, 1,1-dimethylethyl ester

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MSDS Files:: SDS file from LookChem

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Technology Process of Carbamic acid, [(1S)-1-[[(3,4-dimethoxyphenyl)methoxy]methyl]-1-[[[(1,1-dimethylethyl)di methylsilyl]oxy]methyl]-2-propynyl]-, 1,1-dimethylethyl ester

There total 7 articles about Carbamic acid, [(1S)-1-[[(3,4-dimethoxyphenyl)methoxy]methyl]-1-[[[(1,1-dimethylethyl)di methylsilyl]oxy]methyl]-2-propynyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: [1-(3,4-dimethoxy-benzyloxymethyl)-1-hydroxymethyl-prop-2-ynyl]-carbamic acid tert-butyl ester

: 502183-37-1
(S)-[1-(tert-butyldimethylsilanyloxymethyl)-1-(3,4-dimethoxybenzyloxymethyl)prop-2-ynyl]carbamic acid tert-butyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 45 ℃; for 12h;
DOI:10.1021/jo020532t

Reference yield:

: 93-03-8
(3,4-dimethoxyphenyl)methanol

: 502183-37-1
(S)-[1-(tert-butyldimethylsilanyloxymethyl)-1-(3,4-dimethoxybenzyloxymethyl)prop-2-ynyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / KOH; K₂CO₃; tris(3,6-dioxaheptylamine) / toluene / 3 h

2: camphorsulfonic acid / CH₂Cl₂ / 20 °C

3: NH₃ / methanol / 12 h / 20 °C

4: imidazole / dimethylformamide / 12 h / 45 °C

With 1H-imidazole; potassium hydroxide; camphor-10-sulfonic acid; Tris(3,6-dioxaheptyl)amine; ammonia; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo020532t

Reference yield:

: 364631-69-6
(1,1-bis-hydroxymethyl-prop-2-ynyl)-carbamic acid tert-butyl ester

: 502183-37-1
(S)-[1-(tert-butyldimethylsilanyloxymethyl)-1-(3,4-dimethoxybenzyloxymethyl)prop-2-ynyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / DMAP / pyridine / 12 h / 20 °C

2: pig liver esterase; phosphate buffer / acetonitrile / 3 h / 20 °C / pH 6.5

3: camphorsulfonic acid / CH₂Cl₂ / 20 °C

4: NH₃ / methanol / 12 h / 20 °C

5: imidazole / dimethylformamide / 12 h / 45 °C

With 1H-imidazole; dmap; phosphate buffer; pig liver esterase; camphor-10-sulfonic acid; ammonia; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo020532t