Technology Process of Nida-41020
There total 5 articles about Nida-41020 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium bis(trimethylsilyl)amide / diethyl ether; various solvent(s) / -78 - 20 °C
1.2: ethanol / 16 h / 20 °C
1.3: 81 percent / acetic acid / 18 h / Heating
2.1: KOH / methanol / 16 h / Heating
3.1: thionyl chloride / toluene / 3 h / Heating
4.1: 0.51 g / triethylamine / CH2Cl2 / 16 h
With
potassium hydroxide; thionyl chloride; triethylamine; lithium hexamethyldisilazane;
In
methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jm020157x
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium bis(trimethylsilyl)amide / diethyl ether; various solvent(s) / -78 - 20 °C
1.2: ethanol / 16 h / 20 °C
1.3: 81 percent / acetic acid / 18 h / Heating
2.1: KOH / methanol / 16 h / Heating
3.1: thionyl chloride / toluene / 3 h / Heating
4.1: 0.51 g / triethylamine / CH2Cl2 / 16 h
With
potassium hydroxide; thionyl chloride; triethylamine; lithium hexamethyldisilazane;
In
methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jm020157x
- Guidance literature:
-
Multi-step reaction with 2 steps
1: thionyl chloride / toluene / 3 h / Heating
2: 0.51 g / triethylamine / CH2Cl2 / 16 h
With
thionyl chloride; triethylamine;
In
dichloromethane; toluene;
DOI:10.1021/jm020157x
