1H-Pyrazole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-

Base Information

• Chemical Name: 1H-Pyrazole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-
• CAS No.: 501426-60-4
• Molecular Formula: C18H14Cl2N2O3
• Molecular Weight: 377.227
• Mol file: 501426-60-4.mol

Synonyms:

Chemical Property of 1H-Pyrazole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrazole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-

There total 5 articles about 1H-Pyrazole-3-carboxylic acid, 1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-(2,4-dichlorophenyl)-4-methyl-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (501426-48-8) → 1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid (501426-60-4)

Guidance literature:

1-(2,4-dichlorophenyl)-4-methyl-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester; With potassium hydroxide; In methanol; at 60 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In methanol; water; Inert atmosphere; Cooling with ice;

DOI:10.1021/jm900471u

Reference yield: 84.0%

→ 1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid (501426-60-4)

Guidance literature:

Reference yield:

2,4-dichlorophenyl hydrazine hydrochloride (5446-18-4) → 1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid (501426-60-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium bis(trimethylsilyl)amide / diethyl ether; various solvent(s) / -78 - 20 °C

1.2: ethanol / 16 h / 20 °C

1.3: 81 percent / acetic acid / 18 h / Heating

2.1: KOH / methanol / 16 h / Heating

With potassium hydroxide; lithium hexamethyldisilazane; In methanol; diethyl ether;

DOI:10.1021/jm020157x

upstream raw materials:

1-(2,4-dichlorophenyl)-4-methyl-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

2,4-dichlorophenyl hydrazine hydrochloride

4-Methoxypropiophenone

Downstream raw materials:

1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

NIDA 41020

NIDA 41057

2-{4-[2-(2,4-dichloro-phenyl)-4-methyl-5-(piperidin-1-ylcarbamoyl)-2H-pyrazol-3-yl]-phenoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester