1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-N-1-piperidinyl-

Base Information

Chemical Name:1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-N-1-piperidinyl-
CAS No.:502486-92-2
Molecular Formula:C22H22Cl2N4O2
Molecular Weight:445.348
Hs Code.:

Synonyms:

Suppliers and Price of 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-N-1-piperidinyl-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-N-1-piperidinyl-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-N-1-piperidinyl-

There total 6 articles about 1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-N-1-piperidinyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5446-18-4
2,4-dichlorophenyl hydrazine hydrochloride

: 502486-92-2
NIDA 41057

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium bis(trimethylsilyl)amide / diethyl ether; various solvent(s) / -78 - 20 °C

1.2: ethanol / 16 h / 20 °C

1.3: 81 percent / acetic acid / 18 h / Heating

2.1: KOH / methanol / 16 h / Heating

3.1: 96 percent / HBr / acetic acid / Heating

4.1: thionyl chloride / toluene / Heating

5.1: triethyl amine / CH₂Cl₂

With potassium hydroxide; thionyl chloride; hydrogen bromide; triethylamine; lithium hexamethyldisilazane; In methanol; diethyl ether; dichloromethane; acetic acid; toluene;
DOI:10.1021/jm020157x

Reference yield:

: 121-97-1
4-Methoxypropiophenone

: 502486-92-2
NIDA 41057

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium bis(trimethylsilyl)amide / diethyl ether; various solvent(s) / -78 - 20 °C

1.2: ethanol / 16 h / 20 °C

1.3: 81 percent / acetic acid / 18 h / Heating

2.1: KOH / methanol / 16 h / Heating

3.1: 96 percent / HBr / acetic acid / Heating

4.1: thionyl chloride / toluene / Heating

5.1: triethyl amine / CH₂Cl₂

With potassium hydroxide; thionyl chloride; hydrogen bromide; triethylamine; lithium hexamethyldisilazane; In methanol; diethyl ether; dichloromethane; acetic acid; toluene;
DOI:10.1021/jm020157x

Reference yield:

: 501426-60-4
1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

: 502486-92-2
NIDA 41057

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / HBr / acetic acid / Heating

2: thionyl chloride / toluene / Heating

3: triethyl amine / CH₂Cl₂

With thionyl chloride; hydrogen bromide; triethylamine; In dichloromethane; acetic acid; toluene;
DOI:10.1021/jm020157x