2-acetyl-3-hydroxythiophene

Base Information

• Chemical Name: 2-acetyl-3-hydroxythiophene
• CAS No.: 5556-07-0
• Molecular Formula: C6H6O2S
• Molecular Weight: 142.1756
• Hs Code.: 2934999090
• Mol file: 5556-07-0.mol

Synonyms:Ketone,3-hydroxy-2-thienyl methyl (7CI,8CI);2-Acetyl-3-hydroxythiophene;3-Hydroxy-2-thienyl methyl ketone;Thioisomaltol;1-(3-hydroxythiophen-2-yl)ethanone;ethanone, 1-(3-hydroxy-2-thienyl)-;2-Acetyl-3-Hydroxythiophene;

Chemical Property of 2-acetyl-3-hydroxythiophene

Chemical Property:

• Vapor Pressure: 0.013mmHg at 25°C
• Melting Point: 51.5-52.5℃
• Refractive Index: 1.5795 (589.3 nm 20℃)
• Boiling Point: 251.806 °C at 760 mmHg
• PKA: 9.88±0.10(Predicted)
• Flash Point: 106.089 °C
• PSA: 65.54000
• Density: 1.306 g/cm³
• LogP: 1.65630
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

1-(3-hydroxythiophen-2-yl)ethan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-acetyl-3-hydroxythiophene

There total 5 articles about 2-acetyl-3-hydroxythiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-acetyl-3-methoxythiophene (51514-36-4) → 2-acetyl-3-hydroxythiophene (5556-07-0)

Guidance literature:

2-acetyl-3-methoxythiophene; With boron tribromide; In dichloromethane; at -78 - 20 ℃;

With water; In dichloromethane;

Reference yield: 85.0%

2-ACETYL-3-HYDROXYTHIOPHENE-5-CARBOXYLIC ACID → 2-acetyl-3-hydroxythiophene (5556-07-0)

Guidance literature:

copper bronze; In quinoline; at 230 ℃; for 2h;

DOI:10.1080/00397919608003715

Reference yield:

conc. H2 SO4 + propynoic acid methyl ester (922-67-8) + 1-mercaptopropan-2-one (24653-75-6) → 2-acetyl-3-hydroxythiophene (5556-07-0)

Guidance literature:

With hydrogenchloride; sodium hydroxide; NaOCH₃; In water; toluene;

upstream raw materials:

5-Acetyl-4-hydroxy-2-methoxycarbonylthiophene

propynoic acid methyl ester

1-mercaptopropan-2-one

2-acetyl-3-methoxythiophene

Refernces

• 1、 -. "TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE". Page/Page column 45. . Retrieved 2011/07/29.
• 2、 Adamczewska,Barker,Huddleston,Wood. "A synthesis of 2-acyl-3-hydroxythiophenes". . p. 1083 - 1096. Retrieved 2007/10/03.