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Methyl propiolate

Base Information Edit
  • Chemical Name:Methyl propiolate
  • CAS No.:922-67-8
  • Molecular Formula:C4H4O2
  • Molecular Weight:84.0746
  • Hs Code.:29161980
  • European Community (EC) Number:213-083-5
  • NSC Number:154164
  • UNII:T88NXO102K
  • DSSTox Substance ID:DTXSID60238923
  • Nikkaji Number:J87.385C
  • Wikipedia:Methyl_propiolate
  • Wikidata:Q56291556
  • ChEMBL ID:CHEMBL4086262
  • Mol file:922-67-8.mol
Methyl propiolate

Synonyms:METHYL PROPIOLATE;922-67-8;methyl prop-2-ynoate;2-Propynoic acid, methyl ester;Methyl acetylenecarboxylate;Methyl propynoate;Propiolic acid, methyl ester;Methyl ethynecarboxylate;methyl propargylate;Propynoic acid methyl ester;Propynoic acid, methyl ester;Acetylenecarboxylic acid methyl ester;MFCD00008572;methyl 2-propynoate;NSC 154164;EINECS 213-083-5;Propiolic Acid Methyl Ester;BRN 0605462;AI3-37828;T88NXO102K;NSC-154164;4-02-00-01688 (Beilstein Handbook Reference);27342-21-8;Propargylic Acid Methyl Ester;methyl propalate;Methyl propiolate, 99%;propiolic acid methylester;UNII-T88NXO102K;methyl acetylenemonocarboxylate;(CARBOMETHOXY)ACETYLENE;CHEMBL4086262;(METHOXYCARBONYL)ACETYLENE;AMY7053;DTXSID60238923;NSC154164;STK505661;AKOS000120024;SB40750;BP-30045;LS-123962;CS-0022413;FT-0628338;P0528;EN300-20478;P17723;J-522627;F0001-2227

Suppliers and Price of Methyl propiolate
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Methyl Propiolate
  • 1g
  • $ 45.00
  • TCI Chemical
  • Methyl Propiolate >98.0%(GC)
  • 5mL
  • $ 36.00
  • TCI Chemical
  • Methyl Propiolate >98.0%(GC)
  • 25mL
  • $ 162.00
  • SynQuest Laboratories
  • Methyl prop-2-ynoate
  • 100 g
  • $ 180.00
  • SynQuest Laboratories
  • Methyl prop-2-ynoate
  • 25 g
  • $ 61.00
  • SynQuest Laboratories
  • Methyl prop-2-ynoate
  • 5 g
  • $ 28.00
  • Sigma-Aldrich
  • Methyl propiolate 99%
  • 2.5g
  • $ 43.20
  • Sigma-Aldrich
  • Methyl propiolate 99%
  • 10g
  • $ 88.80
  • Sigma-Aldrich
  • Methyl propiolate 99%
  • 50g
  • $ 325.00
  • Oakwood
  • Methyl Propiolate
  • 100g
  • $ 180.00
Total 121 raw suppliers
Chemical Property of Methyl propiolate Edit
Chemical Property:
  • Appearance/Colour:colourless to light yellow liquid 
  • Vapor Pressure:31.438mmHg at 25°C 
  • Melting Point:171-173 °C 
  • Refractive Index:n20/D 1.408(lit.)  
  • Boiling Point:104 °C at 760 mmHg 
  • Flash Point:10 °C 
  • PSA:26.30000 
  • Density:1.028 g/cm3 
  • LogP:-0.20740 
  • Storage Temp.:Refrigerator (+4°C) + Flammables area 
  • Water Solubility.:Not miscible in water. 
  • XLogP3:0.6
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:2
  • Rotatable Bond Count:1
  • Exact Mass:84.021129366
  • Heavy Atom Count:6
  • Complexity:95.4
Purity/Quality:

99% *data from raw suppliers

Methyl Propiolate *data from reagent suppliers

Safty Information:
  • Pictogram(s): FlammableF, IrritantXi 
  • Hazard Codes:F,Xi 
  • Statements: 11-36/37/38-36 
  • Safety Statements: 26-36-36/37/39-23-16-33-7/9 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:COC(=O)C#C
  • Uses Methyl propiolate was used in the synthesis of polysubstituted 3-arylaminoacrylate and tetrahydropyrimidin-2-one derivatives. It was also used as a thiol derivatizing agent for capillary electrophoresis.
Technology Process of Methyl propiolate

There total 17 articles about Methyl propiolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With sulfuric acid; In methanol; dichloromethane; at 40 ℃; for 28h;
Guidance literature:
propynoic acid methyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
carbon dioxide; In tetrahydrofuran; hexane; at 20 ℃; for 1h;
DOI:10.1039/c4ob02114b
Guidance literature:
With sulfuric acid; for 48h;
DOI:10.3390/10111413
Refernces Edit

Facile synthesis of benzo-fused 2,8-dioxabicyclo[3.3.1]nonane derivatives via a domino Knoevenagel condensation/hetero-Diels-Alder reaction sequence

10.1016/j.tet.2007.11.036

The study presents a two-step synthesis method for benzo-fused 2,8-dioxabicyclo[3.3.1]nonane derivatives, utilizing a domino Knoevenagel condensation/intramolecular hetero-Diels-Alder reaction sequence. The process involves an initial intermolecular Knoevenagel condensation of a compound with active methylene compounds to form a heterodiene, which then undergoes intramolecular hetero-Diels-Alder cycloaddition. The research successfully optimized the reaction conditions, including the choice of catalyst and solvent, to achieve high yields of the desired products. The method demonstrates a novel route for constructing complex heterocycles with potential applications in medicinal chemistry.

Facile and Efficient Carboalkoxylation and Carboaryloxylation of Amines

10.1021/jo01310a057

The research explores the synthesis and reactions of various organic compounds. It includes the preparation of indole derivatives using compounds like 1-methyl-2-vinylpyrrole, methyl propiolate, and hydroquinone, resulting in products such as dimethyl indole-6,7-dicarboxylate and methyl 1-tert-butylindole-7-carboxylate, characterized by melting points, IR spectra, NMR spectra, and elemental analysis. Additionally, the study introduces alkyl and aryl α-methoxyvinyl carbonates (3a-c) as efficient reagents for carboalkoxylation and carboaryloxylation of amines, including weakly basic ones, under mild conditions, yielding high-quality N-carboalkoxylated and N-carboaryloxylated compounds. The research also examines the reactions of [3-(dimethylamino)-2-azaprop-2-en-1-ylidene]dimethylammonium chloride with hydrazines and amidines, producing 1,2,4-triazoles and substituted products, with detailed spectral data confirming the structures of the synthesized compounds.

Three-component coupling of isoquinoline, activated alkyne and nitromethane: A facile synthesis of nitromethyl derivatives of 1,2-dihydroisoquinolines

10.1055/s-0028-1088004

The research presents a novel three-component coupling (3CC) reaction involving isoquinoline, activated alkynes, and nitromethane, which produces nitromethyl derivatives of 1,2-dihydroisoquinolines in high yields and with high selectivity. This reaction is notable for its simplicity and mild conditions, as it proceeds smoothly at 25 °C without the need for a catalyst. The study explores the coupling of various substituted isoquinolines and quinolines with different activated alkynes, such as methyl propiolate, ethyl propiolate, and dimethyl acetylenedicarboxylate, yielding the desired products in good to excellent yields. The reaction mechanism is proposed to involve a zwitterionic intermediate. The products are characterized using NMR, IR, and mass spectrometry, confirming the successful synthesis of these nitromethyl derivatives. This method offers significant advantages, including operational simplicity, high product yields, and tolerance of various functional groups, making it a valuable tool for the synthesis of 1-substituted dihydroisoquinolines and 2-substituted quinolines.

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