Methyl-d3-amine hydrochloride

Base Information

• Chemical Name: Methyl-d3-amine hydrochloride
• CAS No.: 7436-22-8
• Molecular Formula: CH2 D3 N . Cl H
• Molecular Weight: 70.4945
• European Community (EC) Number: 231-089-6,946-334-9
• DSSTox Substance ID: DTXSID50225362
• Mol file: 7436-22-8.mol

Synonyms:Methyl-d3-amine hydrochloride;7436-22-8;(2H3)Methylammonium chloride;Trideuteriomethanamine;hydrochloride;EINECS 231-089-6;Methylamine-d3 Hydrochloride;METHYL-D3-AMINE HCL;METHYL-D3-AMINE:HCL (D);MFCD00064559;Methyl-d3-ammonium chloride;trideuteriomethanamine,hydrochloride;CH2D3N.ClH;Methan-d3-amine hydrochloride;C-H2-D3-N.Cl-H;Methyl-D3 Amine Hydrochloride;AMY014;methyl-d3-amine hydrogenchloride;DTXSID50225362;STR10295;AKOS037655938;((2)H?)METHANAMINE HYDROCHLORIDE;Methyl-d3-amine hydrochloride (D3 98%);Methyl-d3-amine hydrochloride, 99 atom % D;W11835;A937429

Chemical Property of Methyl-d3-amine hydrochloride

Chemical Property:

• Vapor Pressure: 3970mmHg at 25°C
• Melting Point: 232-234 °C(lit.)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 70.0377071
• Heavy Atom Count: 3
• Complexity: 2

Purity/Quality:

99.9% ^*data from raw suppliers

Methyl-d3-amine hydrochloride 99 atom % D ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN.Cl
• Isomeric SMILES: [2H]C([2H])([2H])N.Cl
• Uses: MethylaMine-d3 Hydrochloride is useful in preparation of deuterated diphenylurea derivatives as phosphokinase inhibitors.

Technology Process of Methyl-d3-amine hydrochloride

There total 10 articles about Methyl-d3-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C8H8(2)H3N*ClH (122025-10-9) → methyl-d3-amine hydrochloride (7436-22-8)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 40 ℃; Reagent/catalyst; Temperature;

Reference yield: 93.0%

C15H14(2)H3N → methyl-d3-amine hydrochloride (7436-22-8)

Guidance literature:

With hydrogenchloride; 10% palladium hydroxide on charcoal; palladium 10% on activated carbon; hydrogen; In methanol; water; at 50 ℃; for 24h; under 760.051 Torr; Reagent/catalyst;

Reference yield: 88.0%

N-Nitroso-N-methyl-d3-methoxymethylamine (85894-44-6) → methyl-d3-amine hydrochloride (7436-22-8)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Heating;

DOI:10.1021/jo00162a019

upstream raw materials:

N-Nitroso-N-methyl-d₃-methoxymethylamine

(N-(methyl-d3))-isoindole-1,3-dione instead of 2-(N-(methyl-d3))-isoindole-1,3-dione

nitromethane-d3

methylamine hydrochloride

Downstream raw materials:

4-(3-fluoro-4-nitrophenoxy)-N-d3-methylpicolinamide

4-chloropyridinyl-2-(N-1',1',1'-trideuteromethylcarboxamide)

2,4-dinitro-N-trideuteriomethyl-aniline

6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d₃)pyridazine-3-carboxamide

Refernces

• 1、 -. "Deuterated compound and application thereof in treatment of cancer". Paragraph 0129; 0132. . Retrieved 2021/03/06.
• 2、 Liu, Zhaogang,Ren, Xiangyu,Wang, Peng. "A practical synthesis of deuterated methylamine and dimethylamine". . p. 265 - 268. Retrieved 2020/11/30.